Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction.

By A. Fantin, J. Vieira, G. Gestri, L. Denti, Q. Schwarz, Sergey V. Prykhozhij, Francesca Peri, Stephen W. Wilson, C. Ruhrberg. Blood, 2010

1,084 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/02414088caf93193a1d095042d02db6c0abfc80d

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Citations in the corpus

Signal transduction by vascular endothelial growth factor receptors. (2012, background): “Sprouting is completed by lumen formation and the establishment of circulation, as soon as two sprouts anastomose, in a process 6 Cite this article as Cold Spring Harb Perspect Med 2012;2:a006502 w w w .p er sp ec ti ve si n m ed ic in e. o rg guided by macrophages (Fantin et al. 2010).”
Molecular control of endothelial cell behaviour during blood vessel morphogenesis (2011, background): “In particular, certain macrophage populations may act as cellular chaperones that promote vascular anastomosi”
Cellular and physiological mechanisms underlying blood flow regulation in the retina choroid in health disease (2012, positive): “However, recent studies have modified this earlier concept of macrophage association (Penfold et al., 1990; Checchin et al., 2006) to the concept that tissue macrophages act as cellular chaperones for vascular anastomosis (Fantin et al., 2010).”
Basic and therapeutic aspects of angiogenesis. (2011, positive): “By accumulating at sites of vessel anastomosis and interacting with filopodia of neighboring tip cells during fusion, macrophages can support vessel anastomosis (Fantin et al., 2010) (Figure 3A).”
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. (2011, background): “Such scenario is in agreementwith a recent study showing that TIE2+ perivascularmacrophages physically interact with the TIE2+ endothelial tip cells of nascent blood vessels and are essential to promote vascular anastomosis during embryonic development (Fantin et al., 2010).”
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm (2010, background): “Macrophages act as 'bridge cells' or 'cellular chaperones' that guide the fusion of endothelial tip cells (vascular anastomosis) and facilitate vascular sproutin”
Macrophages in skin injury and repair. (2011, neutral): “Instead, macrophages serve as guidance and bridge cells in this fusion process (Fantin et al. 2010).”
Wound Healing: A Cellular Perspective. (2019, background): “Pro-vascular macrophages in the wound are found to express the surface marker Tie2 which is also expressed on endothelial cells and some hematopoietic stem cells (108).”
Wound healing: cellular mechanisms and pathological outcomes (2020, background): “Macrophages also participate in the remodelling of new vasculature, by guiding vessel tips together [75], phagocytosing superfluous vessels [47,76] and dampening the angiogenic response to prevent excessive vascularization [77].”
Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, background): “1 (regulating myeloid protein expression), there was a reduction in the number of vessel intersection was observed leading to abnormal vasculature process and suggesting that macrophage contact with vessel junctions are required to promote vessel fusion (5, 6).”
Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves (2015, background): “To confirm this was not due to loss of VEGF-A expression in ECs we (1) performed bone marrow transplant experiments from Vegfafl/fl Tie2-Cre and control Vegfafl/fl litter-mates into WT mice and found similar defective entry of blood vessels into the bridges of the mice receiving the mutant bone marr”