Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites1
By R. Abe, S. Donnelly, Tina Peng, R. Bucala, C. Metz. Journal of Immunology, 2001
818 citations recorded by the source corpus.
Subfields: Cancer Research, Immunology and Allergy, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/010c196a3cd1a3486eb5ce6ec2df2e4c7d4f649f
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Immunology and Allergy
In Rehabilitation
Citations in the corpus
- Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. (2004, neutral): “One likely mechanism for achieving this is the chemokine receptor CXCR4 and its cognate ligand CXCL12, which has been shown to regulate cellular migration in other systems (6, 15, 16).”
- Bone marrow-derived progenitor cells in pulmonary fibrosis. (2004, positive): “250 The Journal of Clinical Investigation | January 2004 | Volume 113 | Number 2 fibroblasts and myofibroblasts that normally participate in the repair process (11).”
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition (2011, background): “A second proposed source of fibrotic cells is circulating bone marrow-derived fibrocytes (8, 9).”
- Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma1 (2003, methodology): “The dye PKH-26 has been used repeatedly as a viable red fluorescent membrane stain to track the migration and proliferation of hemopoietic stem cells and mature leukocytes in vivo (34–37) and to study the in vivo chemotactic response of circulating fibrocytes to chemokines (29).”
- Role of tissue stroma in cancer cell invasion (2003, background): “TGF-β upregulates α-SMA expression in fibrocytes and transdifferentiates them into myofibroblasts (Figure 1) [132].”
- Transforming growth factor–β in tissue fibrosis (2020, background): “Although investigations in both animal models and human patients have identified “fibrocytes” as mesenchymal cells derived from circulating monocyte precursors (Abe et al., 2001; Reilkoff et al., 2011), their contribution to the fibrotic process remains poorly documented.”
- Formation and function of the myofibroblast during tissue repair. (2007, background): “In addition, fibroblasts may originate from fibrocytes, a sub-population of bone marrow-derived leukocytes with fibroblast characteristics (Abe et al., 2001).”
- Perspective Article: Tissue repair, contraction, and the myofibroblast (2005, background): “These cells can be induced by TGF-b1 to express a-SMA, and they readily contract collagen gels in vitro.(33) Clinically, there is evidence that patients with hypertrophic scars and other fibrosing disorders have fibrocytes in their lesions (for review, see(34)).”
- Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration (2007, background): “Systemic cells are populations of cells that are resident in the blood or bone marrow system, an example of which would be fibrocytes, known to play a key role in skin wound healing (Bucala et al. 1994; Abe et al. 2001).”
- Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “If the wound condition is long lasting, fibroblasts in the wounds may also originate from fibrocytes, which is a group of bone marrow-derived mesenchymal progenitor cells [37, 38].”