Transforming growth factor–β in tissue fibrosis
By Nikolaos G. Frangogiannis. Journal of Experimental Medicine, 2020
905 citations recorded by the source corpus.
TGF-β is a central mediator in the fibrotic response. This review discusses the role of TGF-β in tissue fibrosis, highlighting the mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.
Subfields: Molecular Biology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/6a4df8703ffa8c1524a7d31477d6e95e88cecd1c
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In Molecular Biology
In Pathology and Forensic Medicine
Citations in the corpus
- Cardiac fibrosis. (2020, background): “1 TGF-bs in cardiac fibrosis TGF-b is the best characterized fibrogenic growth factor.(210,211) In mammals, the TGF-b subfamily is comprised of three isoforms (TGF-b1, 2, and 3)(212) that signal through the same receptors and share common cel-”