Role of tissue stroma in cancer cell invasion

By O. De Wever, M. Mareel. Journal of Pathology, 2003

1,094 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/201cd7413c9c29c4d73c8d605ee415c356b6cc38

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

A Deep Convolutional Neural Network for segmenting and classifying epithelial and stromal regions in histopathological images (2016, background): “Although ST tissue is typically considered as not being part of malignant tissue, the changes in the stroma tend to drive tumor invasion and metastasis [11].”
Stromal myofibroblasts are drivers of invasive cancer growth (2008, methodology): “A number of review articles covering this topic in more detail have been published recently.(2,10) For example, in breast invasive ductal carcinoma (IDC) and micropapillary carcinoma (a rare and aggressive variant of IDC), CD341 stromal cells disappear and a-SMA1 myofibroblasts are abundant.”
TGFβ in Cancer (2008, background): “TGFβ stimulates the generation of myofibroblasts from mesenchymal precursors (De Wever and Mareel, 2003) (Figure 6).”
TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013, background): “Most of the cells in the tumor microenvironment are fibroblasts, that is, CAFs, which express a-smooth muscle actin and closely resemble myofibroblasts, and these stromal fibroblasts promote cancer progression [73].”
Molecular characterization of the tumor microenvironment in breast cancer. (2004, background): “, tracellular matrix remodeling , wound healing , and chronic in - flammation ( De Wever and Mareel , 2003 ; Gabbiani , 1999 ; 2003 ; Sternlicht and Barsky , 1997 ; Tlsty , 2001 ; Tlsty and Hein , 2001 ; Wiseman and Werb , 2002 ) .”
Formation and function of the myofibroblast during tissue repair. (2007, background): “In addition, myofibroblast participation to the process called stroma reaction promotes cancer progression by creating a stimulating microenvironment for epithelial tumor cells (De Wever and Mareel, 2003; Desmouliere et al., 2004).”
Friends or foes — bipolar effects of the tumour stroma in cancer (2004, background): “The factors also activate surrounding stromal cell types, such as fibroblasts, smooth-muscle cell”
Cancer-associated stromal fibroblasts promote pancreatic tumor progression. (2008, background): “In many solid tumors, the stroma is increasingly recognized to be important in promoting tumor proliferation, invasion, metastasis, and chemoresistance (2, 4).”
Tumor-stroma ratio is an independent predictor for survival in early cervical carcinoma. (2014, background): “Stroma quantity and quality influence cancer initiation, progression, metastasis, and hold prognostic potential [5,6].”
Patient Derived Xenograft Models: An Emerging Platform for Translational Cancer Research (2014, background): “This new murine stroma probably results in changes in paracrine regulation of the tumor as well as in physical properties such as interstitial pressure, that may limit the study of agents directed against this tumor compartment (50, 60).”