Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma1

By Matthias Schmidt, G. Sun, M. Stacey, L. Mori, S. Mattoli. Journal of Immunology, 2003

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Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. (2004, positive): “Further support for the notion that circulating fibrocytes may ultimately differentiate into myofibroblasts within the lungs stems from our observations and other recent reports (6, 11) that cultured human fibrocytes eventually lose expression of CD34 and CD45 and upregulate”
Perspective Article: Tissue repair, contraction, and the myofibroblast (2005, background): “The role of fibrocytes has also been underlined in asthma.(36) Recently, by analyzing the tissue of humans and mice that received either sex-mismatched organ transplants or bone marrow transplants, bone marrowderived myofibroblasts participating in fibrogenic reactions have been identified in severa”