Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.

By R. Phillips, M. Burdick, Kurt M. Hong, M. Lutz, L. Murray, Y. Xue, J. Belperio, M. Keane, R. Strieter. Journal of Clinical Investigation, 2004

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The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? (2008, neutral): “14 5 anti-CXCL12 antibody early (Phillips et al., 2004)”
Cellular and molecular mechanisms of fibrosis (2008, background): “In mice, CXC chemokine receptor 4 (CXCR4), CC chemokine receptor 7 (CCR7) and CCR2 have also been shown to regulate the recruitment of fibrocytes to the lung [20,21].”
Murine models of pulmonary fibrosis. (2008, background): “Phillips and colleagues (70) showed that intravenously introduced human fibrocytes migrate into the mouse lung following bleomycin challenge, and these recruited cells appeared to contribute to the injury (70).”
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak (2008, background): “We and others have reported evidence that inhibition of fibroblast migration can attenuate pulmonary fibrosi”
Integrating mechanisms of pulmonary fibrosis (2011, background): “JEM Vol. 208, No. 7 1343 Review by facilitating the recruitment of bone marrow–derived collagen–secreting fibrocytes to the lung (Phillips et al., 2004; Moore et al., 2005, 2006).”