Genome-wide analysis of Polycomb targets in Drosophila melanogaster

By Y. Schwartz, T. Kahn, D. Nix, Xiaoyong Li, Richard Bourgon, Mark D. Biggin, Vincenzo Pirrotta. Nature Genetics, 2006

651 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/009c7f2aa087d67bf77a7ae8363264132ae9ff2e

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Citations in the corpus

Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis (2007, background): “In Drosophila, PRC1 and PRC2 are recruited to nucleosome-depleted regions of the genome called Polycomb response elements (PREs) primarily through the sequencespecific binding activity of Pho [1,5–10].”
Histone methylation by PRC2 is inhibited by active chromatin marks. (2011, background): “, 2009), a mechanism implicated in creating and maintaining the extended H3K27me3 domains at target genes in vivo (Bernstein et al., 2006; Pan et al., 2007; Papp and Müller, 2006; Schwartz et al., 2006).”
The mammalian epigenome. (2007, background): “Notably, the gypsy transposable element in D. melanogaster insulates against Polycomb-mediated repression and can halt the spreading of H3K27 methylation (Kahn et al., 2006; Mallin et al., 1998; Sigrist and Pirrotta, 1997).”
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. (2007, background): “Schwartz et al., 2006; Squazzo et al., 2006; Tolhuis et al., 2006).”
Comprehensive analysis of the chromatin landscape in Drosophila (2010, background): “1d) 28,29 .”
Transcriptional regulation by Polycomb group proteins (2013, background): “; and from the Novo Nordisk Foundation, the Danish Cancer Society and the Danish Council for Strategic Research (12-110503) to K.”
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes (2014, neutral): “Van Bortle K, Ramos E, Takenaka N, Yang J, Wahi JE, Corces VG. Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains.”
Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition (2014, background): “In cycle 14 embryos, regions both upstream and downstream of the promoters of zygotically expressed genes were enriched for the Polycomb-associated mark H3K27me3 (Figure 5), while the mark was almost completely absent from maternal genes, consistent with the known role of Polycomb group proteins in ”
Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014, background): “…in mammals demonstrating that PRC1 occupancy and H2AK119ub1 can be achieved in the absence of PRC2 (Pasini et al., 2007; Schoeftner et al., 2006; Tavares et al., 2012) and observations in Drosophila suggesting that H3K27me3 is not sufficient to recruit PRC1 complexes (Schwartz et al., 2006).”
Polycomb silencers control cell fate, development and cancer (2006, background): “Nevertheless, the majority of PcG target genes show extensive H3K27me 3 that typically extends well beyond the promoter regio”
The Polycomb Complex PRC2 and its Mark in Life (2011, background): “In Drosophila , domains enriched in H3K27me3 were found to cover large regions of the genome, usually exceeding 10 kilobases (kb”
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms (2008, background): “As expected, a strong overlap between PRC2, PRC1, and H3K27me2/3 was observed ular Cell 32, 503–518, November 21, 2008 ª2008 Elsevier Inc. 503 (Boyer et al., 2006; Bracken et al., 2006; Lee et al., 2006; Schwartz et al., 2006).”
Genome-wide identification of Polycomb-associated RNAs by RIP-seq (2010, background): “…(Kapranov et al., 2007; Core et al., 2008; Seila et al., 2008; Taft et al., 2009), PRC2’s preferred occupancy near promoters (Boyer et al., 2006; Lee et al., 2006; Schwartz et al., 2006; Ku et al., 2008), and identification of several TSS-associated RNAs which bind PRC2 (Kanhere et al., 2010).”
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting. (2017, positive): “Moreover, a recent report demonstrated that a subset of Drosophila PREs can function as developmental enhancers in vivo, activating transcription in specific spatial domains (Erceg et al., 2017).”