Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells.

By Xiao Dong Zhao, Xu Han, Joon-Lin Chew, Jun Liu, K. Chiu, A. Choo, Y. Orlov, W. Sung, Atif Shahab, V. Kuznetsov and 5 more. Cell Stem Cell, 2007

615 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/051f2e4aa80c8479bca1e772c8285b37189fb562

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Citations in the corpus

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “…are consistent with recent observations that H3K4me3 associates extensively with proximal promoters in human T cells, as well as human and murine embryonic stem cells (Barski et al., 2007; Fouse et al., 2008; Guenther et al., 2007; Mikkelsen et al., 2007; Pan et al., 2007; Zhao et al., 2007).”
A double take on bivalent promoters. (2013, background): “Bivalent genes were further identified in human ES cells (Pan et al. 2007; Zhao et al. 2007).”
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, methodology): “Histone methylation status in sperm versus somatic cells To relate genomic localization to chromatin regulation during development, we compared ChIP patterns in sperm to those generated in human embryonic stem cells (hESCs) and primary fibroblast”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “Many promoters of key regulators further bear the ‘‘active’’ lysine 4 methylation mark on histone H3 (H3K4) in addition to the repressive Polycomb-mediated H3K27 methylation (Bernstein et al., 2006; Mikkelsen et al., 2007; Pan et al., 2007; Zhao et al., 2007).”
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, background): “domains may reflect multiple, distinct regulatory entities [16–18].”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “Studies using ESCs suggest that bivalent modifications maintain the activation or silencing potential of critical differentiation genes (Azuara et al., 2006; Bernstein et al., 2006).”