Transcriptional regulation by Polycomb group proteins

By Luciano Di Croce, K. Helin. Nature Structural &Molecular Biology, 2013

878 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer (2017, neutral): “Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that methylates lysine 27 of histone H3 to promote transcription silencing [8, 9].”
Interpreting thelanguage of histone and DNA modifications (2014, background): “H3K27me3 (marks of facultative heterochromatin written by the EZH2 subunit of the PRC2 complex [94]) as well as H4K20me1 (written by PR-Set7 and involved in the DNA damage response and mitotic chromatin condensation [95]), populations of symmetrically and asymmetrically modified nucleosomes were ide”
The physics of epigenetics (2015, background): “…binding for nucleosome arrays with long but not with short DNA linkers, pointing to a facilitated spreading of HP1 on long NRL substrates. b. Polycomb-mediated heterochromatin Polycombs are family proteins that mediate transcriptional silencing (Di Croce and Helin, 2013; Simon and Kingston, 2013).”
Cancer epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance (2014, background): “In this view, the degree of the H3K27me3 occupancy builds by default when transcription is low (Di Croce and Helin, 2013).”