The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

By P. A. Gregory, A. Bert, Emily Paterson, S. Barry, Anna Tsykin, G. Farshid, Mathew A. Vadas, Y. Khew-Goodall, Gregory J. Goodall. Nature Cell Biology, 2008

3,938 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9fa2346d57ce99d3da12153ca6ceb917390cf83b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Weinberg
2. H. Horlings
3. M. Nieto
4. Thomas Brabletz
5. Jing Yang
6. Carlo Maria Croce
7. K. Yeung
8. J. P. Thiery

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Thomas Brabletz
4. Jing Yang
5. J. P. Thiery
6. Simone Brabletz
7. R. Derynck
8. K. Yeung

Citations in the corpus

• Poised chromatin at the ZEB1 promoter enables cell plasticity and enhances tumorigenicity (2013, neutral): “ZEB1 itself, its relative ZEB2, and members of the MIR200 family of microRNAs (Gregory et al., 2008; Wellner et al., 2009).”
• EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer (2010, background): “Most significantly, EMT is regulated by the expression of the mir-200 family and mir-205 (Burk et al., 2008; Gregory et al., 2008; Korpal et al., 2008; Park et al., 2008).”
• A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. (2010, background): “, 2007), and upregulation (albeit more delayed) of miR-205 and -429 (Figure 1F; Gregory et al., 2008; Park et al., 2008), which have the opposite role.”
• miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis (2010, background): “In addition, the miR-200 family has emerged as a silencer of ZEB1 and ZEB2, two established EMT-inducing and metastasis-promoting transcription factor”
• Epithelial-mesenchymal transitions in development and disease. (2009, background): “MicroRNAs of the miR-200 family (as well as miR-205) have been shown to control EMT by downregulating the expression of the Zeb factors (Christoffersen et al., 2007; Gregory et al., 2008; Hurteau et al., 2007; Korpal et al., 2008; Park et al., 2008) and to control the metastatic ability”
• Cadherins and cancer: how does cadherin dysfunction promote tumor progression? (2008, background): “, 2008); and the transcriptional repressors SIP1 and ZEB1, the aberrant expression of which may, in turn, reflect loss of inhibitory microRNAs (Gregory et al., 2008).”
• MicroRNA control of signal transduction (2010, background): “The miR-200 family of miRNAs plays a major part in specifying the epithelial phenotype by preventing the expression of the transcriptional repressors of E-cadherin, ZEB1 and ZEB2 (Ref”
• The RNA binding protein quaking regulates formation of circRNAs. (2015, positive): “miRNAqRTPCR was performed with TaqMan assay as per Gregory et al. (2008). RT-PCR”
• Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes (2010, background): “Recent findings have demonstrated that EMT programs can also be induced by inhibiting members of the miR-200 family of microRNAs (17, 18, 32).”
• Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling (2011, background): “miRNAs have been shown to control various key processes in tumorigenesis, such as tumor initiation (13), metastasis (15, 16), inflammation (17), and differentiation (18) in cell lines and animal models.”
• In vivo identification of tumor suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma (2011, positive): “The ZEB2 protein promotes EMT by repressing expression of E-Cadherin (Vandewalle et al., 2005) and thus may be involved in promoting cancer progression and metastasis in some instances of epithelial cancers.”