Kindlin-3 is essential for integrin activation and platelet aggregation

By M. Moser, B. Nieswandt, S. Ussar, M. Požgajová, R. Fässler. Nature Medicine, 2008

717 citations recorded by the source corpus.

Subfields: Hematology, Immunology and Allergy, Surgery

View Paper: https://www.semanticscholar.org/paper/54e638d1f4628047fa74369924e3090a9baf1517

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Citations in the corpus

Integrins (2009, background): “When kindlin-3 is mutated, integrin activation in leukocytes and platelets fails (Moser et al. 2008; Svensson et al. 2009), demonstrating the central role of kindlin-3 for integrin activation on these cell types.”
The final steps of integrin activation: the end game (2010, background): “Mice deficient in kindlin 3 die with diffuse haemorrhages and osteopetrosis shortly after birt”
Integrin structure, activation, and interactions. (2011, background): “In particular, PTB domains bind to one of the two conserved NPXY motifs in b-tails.”
Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. (2011, background): “However, to achieve maximal integrin activation, the cooperation of another anchoring protein, kindlin, which binds to b integrin tails distinct from those used by talin is required (Moser et al. 2008).”
Integrin signalling at a glance (2009, background): “In recent major advances, the first set of these factors – the proteins of the kindlin family – have been identified (Ma et al., 2008; Montanez et al., 2008; Moser et al., 2008).”
Ischemia and reperfusion—from mechanism to translation (2011, background): “Platelet activation can occur through integrin-mediated endothelial interaction”
Neutrophils, from marrow to microbes. (2010, background): “Kindlin 3 gene-targeted mice display defective integrin activation (Moser et al., 2008, 2009a, 2009b) Mutations of kindlin 3 were recently discovered as cause of congenital leukocyte adhesion deficiency LAD III.”
Integrin Structure and Function (2010, background): “Mouse platelets lacking kindlin-3 are unable to organize their cytoskeleton or establish stable lamellipodia (Moser et al. 2008), providing evidence for the importance of the kindlin interactions with the cytoskeleton.”
Environmental sensing through focal adhesions (2009, background): “Talins have a unique role in the formation and maintenance of focal adhesions, as they not only link integrin to actin filaments but, together with the essential integrin-binding proteins kindlin 2 (also known as FERMT2 and MIG2) and kindlin 3 (also known as FERMT3”
Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “In mice, platelets lacking Kindlin-3 expression are unable to organize their cytoskeleton or establish stable lamellipodia upon Mn2-triggered integrin ligation (Moser et al. 2008).”