The integrins
By Yoshikazu Takada, Xiao-yu Ye, Scott I. Simon. Genome Biology, 2007
786 citations recorded by the source corpus.
SummaryThe integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane αβ heterodimers and at least 18 α and eight β subunits are known in humans, generating 24 heterodimers. Members of this family have been found in mammals, chicken and zebrafish, as well as lower eukaryotes, including sponges, the nematode Caenorhabditis elegans (two α and one β subunits, generating two integrins) and the fruitfly Drosophila melanogaster (five α and one β, generating five integrins). The α and β subunits have distinct domain structures, with extracellular domains from each subunit contributing to the ligand-binding site of the heterodimer. The sequence arginine-glycine-aspartic acid (RGD) was identified as a general integrin-binding motif, but individual integrins are also specific for particular protein ligands. Immunologically important integrin ligands are the intercellular adhesion molecules (ICAMs), immunoglobulin superfamily members present on inflamed endothelium and antigen-presenting cells. On ligand binding, integrins transduce signals into the cell interior; they can also receive intracellular signals that regulate their ligand-binding affinity. Here we provide a brief overview that concentrates mostly on the organization, structure and function of mammalian integrins, which have been more extensively studied than integrins in other organisms.
Subfields: Cancer Research, Immunology, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/fad49c016b25e94cfcf4c57b5bce0dd949e439b8
Citations in the corpus
- Integrin Structure and Function (2010, neutral): “For example, aIIbb3 is only found on platelets, a6b4 on keratinocytes, and aEb7, a4b7, a4b1, and the b2 integrin families are restricted to leukocytes (Takada et al. 2007).”
- Integrins (2009, neutral): “Collagen”
- Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, neutral): “Up to now, about 24 unique integrin heterodimers have been uncovered, which consist of 18 α subunits and 8 β subunits through noncovalent binding.(309,310) Each integrin subunit includes a single transmembrane domain, an extracellular region, and a cytoplasmic region with a short chain.”