Getting to the site of inflammation: the leukocyte adhesion cascade updated

By Klaus Ley, C. Laudanna, M. Cybulsky, S. Nourshargh. Nature reviews. Immunology, 2007

4,446 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/20ca6ce5064c6135977d21eae20f3f96140bedfb

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Citations in the corpus

The Structure of Glycosaminoglycans and their Interactions with Proteins (2008, background): “processes, as adhesion ligands in leukocyte extravasation and carriers/presenters of chemokines and growth factors (37).”
Monocytes in atherosclerosis: subsets and functions (2010, background): “During atherosclerosis During the pathogenesis of atherosclerosis, blood monocytes are recruited into intima and subintima ( Figure 2a )”
Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “A highly sophisticated machinery directing neutrophil migration (Ley et al., 2007; Nourshargh et al., 2010) and a surprising complexity of neutrophil granules (Borregaard et al., 2007) also begun to emerge.”
Cellular and molecular mechanisms of skin wound healing (2024, neutral): “…down the rolling neutro phils so they can spread and crawl along the luminal surface of vessels until they can migrate across the endothelial and pericyte layers, exit from the blood vessels into the surrounding area (diapedesis), and begin their interstitial migration towards the wound 81,82 (Fig.”
Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. (2013, background): “lium and counter-receptors for endothelial CAMs (for example, LFA-1) on the circulating leukocytes plays critical role in these leukocyte recruitmentprocesses.(31,32) It iswellknown that inflammatory cytokines including TNF-R induce the cell surface expression of CAMs in vascular endothelial cells.”
Hepatic inflammatory responses in liver fibrosis (2023, positive): “…transcriptomic profile and secretome of liver sinusoidal endothelial cells 191 and the infiltration of immune cells, as adhesion and transmigration of leukocytes to sites of inflammation or injury are mediated through ECM receptors on their surface 192 , which has been shown in mice and in vitro.”
The blood-brain barrier in Alzheimer's disease (2017, neutral): “The expression of vascular adhesion molecules that mediate leukocyte traf ﬁ cking is minimal or undetectable under physiological conditions, with P-selectin, E-selectin and ICAM-1 immunoreactivity detected in pial and choroid plexus venules in the normal brain (Kivisäkket al., 2003).”
The immunology of sepsis (2008, background): “We were able to look at underlying mechanisms in the HLA-DR transgenic mouse toxic shock model, in which females are highly susceptible and males resistant [35].”
Mesenchymal stem cell homing: the devil is in the details. (2009, neutral): “To provide context, leukocyte rolling has been typically observed to be less than 5 mm/s at shear stresses up to 4 dynes/cm(2) (Goetz et al., 1994; Ley et al., 2007).”
ICAM-1 signaling in endothelial cells (2009, background): “sion molecules (JAMs) and CD99 (reviewed in [48]).”