T cell-specific loss of Pten leads to defects in central and peripheral tolerance.

By Akira Suzuki, Manae Tsukio Yamaguchi, T. Ohteki, Takehiko Sasaki, T. Kaisho, Y. Kimura, Ritsuko Yoshida, A. Wakeham, T. Higuchi, M. Fukumoto and 6 more. Immunity, 2001

631 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fee7ab36584f8b91ddd0af412250f71d9f8ea4c9

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Citations in the corpus

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. (2004, methodology): “Ptenflox/flox mice (129Ola × C57BL6/J F2), generated as previously described (14), were mated to AlbCre transgenic mice (C57BL6/J background; The Jackson Nonstandard abbreviations used: acetyl-CoA carboxylase (ACC); acyl-CoA oxidase (AOX); alanine aminotransferase (ALT); alkaline phosphatase (ALP); ”
PI3K in lymphocyte development, differentiation and activation (2003, background): “Cre-mediated deletion of PTEN restricted to T cells results in a fatal lymphoproliferative disease, with 100% mortality by 17 weeks of ag”
Pten regulates neuronal arborization and social interaction in mice. (2006, neutral): “Mice and Histology Pten loxP mice (Suzuki et al., 2001) were a gift from Tak Mak (University of Toronto), and Rosa26R mice were from Jackson Lab (Bar Harbor, ME).”
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia (2007, background): “Furthermore, PTEN deficiency has been proposed to have a role in the pathogenesis of T-cell tumors on the basis of studies in Pten knockout mic”
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes (2008, background): “In mice with T lymphocyte–specific loss of PTEN, both central and peripheral tolerance are compromised and the mice develop autoimmunity and T cell lymphoma with a latency of a few week”
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism (2006, background): “In lymphocytes, loss of PTEN leads to hyper-proliferation and resistance to apoptosi”
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007, neutral): “Moreover, mice with T cell-specific deletion of Pten uniformly develop T cell lymphomas (Suzuki et al., 2001).”
The enemy within: keeping self-reactive T cells at bay in the periphery (2002, neutral): “cgi?l=19211">Pten (phosphatase and tensin homolog”
Vaccines: Effector and memory T-cell differentiation: implications for vaccine development (2002, neutral): “cgi?/&lD=207&ID=208&ID=10000">AKT kinase, because PTEN −/− T cells had increased AKT kinase activity and were resistant to superantigen-induced deletion in vivo”