Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

By C. Jopling, M. Yi, Alissa M. Lancaster, S. Lemon, P. Sarnow. Science, 2005

2,628 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/feae259be60cdb806a696f6e54d054dfa2fa7b4a

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Citations in the corpus

MicroRNA control in the immune system: basic principles. (2009, background): “The tissue specificity of miR-122 expression also helps HCV to establish its tissue selectivity (Jopling et al., 2008; Jopling et al., 2005).”
How do microRNAs regulate gene expression? (2008, background): “IRES and was necessary for the replication of the viral RNA, without having any direct effect on its translation ( 70 ).”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “Consistent with that possibility, the replication of the hepatitis C virus appears to be enhanced by the miR-122 miRNA (Jopling et al. 2005).”
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp™ (2014, background): “miR-122 has been linked to important human diseases, such as hepatitis C, liver cancer, and hypercholesterolemia, and its target genes have been well characterized (Jopling et al., 2005; Krützfeldt et al., 2005; Esau et al., 2006; Tsai et al., 2009).”
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, background): “…here that miR-10a binds RP mRNAs at the 50UTR downstream of the conserved 50TOP motif known to regulate translation. miRNA regulation via 50UTR binding is not unprecedented, as miR122 was previously found to bind the 50UTR of hepatitis C virus and modulate viral replication (Jopling et al., 2005).”
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes (2007, background): “It has been shown that a cellular miRNA is able to enhance the replication of hepatitis C virus by an unknown mechanis”
MicroRNAs in development and disease. (2011, background): “With the advent of miRNAs, it was also noted that HCV only replicates in the hepatoma cell lines that have detectable miR-122 (Huh7) but not those that are deficient in this miRNA (HepG2) (284).”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “The hepatitis C virus (HCV) was shown to require binding of the liver-specific miRNA, miR-122 (Jopling et al. 2005), for efficient replication.”
miR-122--a key factor and therapeutic target in liver disease. (2015, background): “Concept Mechanism Examples References miRNA-binding to viral genome or transcript miRNA-induced stability or decay/ translational repression of the viral RNA • miR-122 binds to the HCV genome and enhances viral translation and replication • miR-199a and miR-210 bind to HBsAg mRNA leading to reduced ”
microRNA-122 stimulates translation of hepatitis C virus RNA (2008, background): “Jopling et al (2005) reported that sequestration of miR-122 by antisense oligonucleotides resulted in decreased accumulation of viral genomes.”
microRNA as Biomarkers and Diagnostics (2016, background): “…2010a). miR-122 facilitated replication of the HCV viral RNA by binding selectively to the 5’ non-coding end of the viral genome (Jopling et al., 2005; Scaria et al., 2006), and knockdown of miR-122 resulted in a significant loss of autonomously replicating HCV viral RNAs (Jopling et al., 2005).”
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties (2009, positive): “Interestingly, the efficiency of HCV replication has been found to be closely correlated with the miR-122 expression levels (Jopling et al., 2005; Chang et al., 2008), and further studies have implicated miR-122 in HCV translation, suggesting the involvement of miR-122 in HCV tropism to the liver (H”