Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes

By Jialing Huang, Feng-xiang Wang, E. Argyris, Keyang Chen, Zhihui Liang, Heng Tian, Wenlin Huang, Kathleen Squires, Gwen Verlinghieri, Hui Zhang. Nature Medicine, 2007

807 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/be55e51579ac603b2e2e22ebbd5a118da1faf22c

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In Cancer Research

1. Rebecca L. Skalsky
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3. Bryan R. Cullen
4. Yu Li
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Citations in the corpus

• MicroRNAs in development and disease. (2011, background): “2-kb region at the 3= end of the viral genome and inhibit all viral gene expression and replication (249).”
• Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study (2015, background): “IL-6 has been linked with circulating levels of miR-21 in the past [49] and three of the miRNAs that associate with CD4+ T cell count in our study (miRs -31, -150 and -223) have been linked previously with HIV-1 pathogenesis [37, 38, 57, 68].”
• MicroRNAs in Common Human Diseases (2012, background): “On the contrary, copies of miR-28, miR-125b, miR-150, miR-223 and miR-382 are maintained at high levels in resting CD4 T cells, but significantly decreased in activated CD4 T cells, resulting in productive infection of HIV-1 in only the latter case [76].”
• Viruses, microRNAs, and Host Interactions (2010, background): “Similarly, several cellular miRNAs were reported to target HIV-1 RNAs in cultivated resting CD4+ T cells to maintain HIV-1 latency (47).”