Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

By G. Hoeffel, Yilin Wang, M. Greter, Peter See, P. Teo, B. Malleret, M. Leboeuf, Donovan Low, Guillaume Oller, Francisca F. Almeida and 10 more. Journal of Experimental Medicine, 2012

766 citations recorded by the source corpus.

Langerhans cell precursors initially arise from yolk sac progenitors, but are later superseded by fetal liver monocytes.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/0a4e25b0001375ade10609708c8020dad6925954

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In Immunology

1. Steffen Jung
2. A. Mildner
3. P. Italiani
4. D. Boraschi
5. M. Guilliams
6. Florent Ginhoux
7. C. Varol
8. S. Gordon

Citations in the corpus

• Development and function of dendritic cell subsets. (2014, unknown): “The LC compartment is established before birth from fetal liver-derived monocytes (Hoeffel et al., 2012), and LCs self-renew under physiological steady-state conditions without replacement by blood-borne precursors (Merad et al.”
• Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, methodology): “5 (Naito et al., 1996; Hoeffel et al., 2012, 2015).”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “Fate-mapping experiments have shown that the adult microglial cell population is exclusively derived from yolk sac progenitors (87, 88), whereas for LC in adult skin it was clearly demonstrated a mixed origin, from the yolk sac and from the fetal liver (12, 89).”
• Macrophages: development and tissue specialization. (2015, background): “Aside from epidermal LCs (170), microglia were the first cells of the innate immune system that were experimentally proven to be long-lived and independent of BM-derived myeloid cell replenishment during adulthood (171, 172).”
• The Metabolic Signature of Macrophage Responses (2019, background): “However, it is now established that while monocyte-derived macrophages have origin in the bone marrow by definitive haematopoiesis, tissue macrophage progenitors derive from yolk sac and fetal liver, during primitive and definitive haematopoiesis (2).”
• Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “specialized macrophage-like cells (23) that originate from yolk sac precursors (100, 101) and persist through adult life in close contact with clusters of keratinocytes, reciprocally exchanging survival and trophic factors.”