Fear extinction in rats: implications for human brain imaging and anxiety disorders.

By Mohammed R. Milad, Scott L. Rauch, R. Pitman, Gregory J. Quirk. Biological Psychology, 2006

608 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/fd4b12eec6445c92473eeb8207f94df3d0ae9060

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In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

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Citations in the corpus

The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007, background): “[381]), behavioral inhibition (Tillfors [382]; Levy [383]), and coping with controllable stressors (Ter Horst [384]; Gerrits et al.”
Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. (2006, background): “2005) suggest that increased activity in IL suppresses fear after extinction (Milad et al. 2006; Quirk et al. 2006).”
Extinction circuits for fear and addiction overlap in prefrontal cortex. (2009, background): “Extinction failure in the aversive domain can lead to anxiety disorders (Delgado et al. 2006; Milad et al. 2006), while extinction failure in the appetitive domain can lead to relapse in addicted subjects (Kalivas et al. 2005; Garavan and Hester 2007).”
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress (2012, background): “Human neuroimaging findings predicted that fear extinction recall and its associated network would be impaired in PTSD patients (Milad et al. 2006).”
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (2007, background): “Although the ventromedial prefrontal cortex in rodents is not an exact homologue of the human rostral anterior cingulate cortex and the ventromedial prefrontal cortex, the shared roles of these areas in fear extinction suggest some degree of analogous function (105) and support a translational appro”
How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective (2011, unknown): “This inhibition of the amygdala serves to suppress fear (Milad et al., 2006; Rauch, Shin, & Phelps, 2006), thereby allowing control over behavioral reactions to emotions (Price, 2005).”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “A recent meta-analysis showed that the prefrontal areas deficient in PTSD correspond to the same areas implicated in extinction (Milad et al, 2006).”
RESILIENCE TRAINING THAT CAN CHANGE THE BRAIN (2018, background): “A brain region that is critical for extinction learning is a subdivision of the MPFC that sends robust projections to amygdala neurons that can inhibit the fear response (Milad et al., 2006).”
Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. (2007, background): “…Milad and Quirk 2002). ndeed, on the basis of data in rodents and in patients with nxiety disorders, several investigators have hypothesized that he human vmPFC plays a specific role in extinction recall Maren and Quirk 2004; Milad et al. 2006; Rauch et al. 1998, 2006; otres-Bayon et al. 2004).”
Optogenetic investigation of neural circuits underlying brain disease in animal models (2012, background): “Indeed, an animal model of the processes that may be dysfunctional in PTSD is fear extinction, in which fear responses are gradually eliminated once the aversive stressor is no longer presented with the previously associated contextual stimulu”
Working Memory: Theories, Models, and Controversies (2015, unknown): “Human neuroimaging findings predicted that fear extinction recall and its associated network would be impaired in PTSD patients (Milad et al. 2006).”