Optogenetic investigation of neural circuits underlying brain disease in animal models

By K. Tye, Karl Deisseroth. 2012

738 citations recorded by the source corpus.

Optogenetic tools have provided a new way to establish causal relationships between brain activity and behaviour in health and disease. Although no animal model captures human disease precisely, behaviours that recapitulate disease symptoms may be elicited and modulated by optogenetic methods, including behaviours that are relevant to anxiety, fear, depression, addiction, autism and parkinsonism. The rapid proliferation of optogenetic reagents together with the swift advancement of strategies for implementation has created new opportunities for causal and precise dissection of the circuits underlying brain diseases in animal models.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Malenka
2. K. Tye
3. Anthony A. Grace
4. S. Lammel
5. Karl Deisseroth
6. B. Lim
7. Garret D. Stuber
8. R. Wise

In Cognitive Neuroscience

1. R. Malenka
2. K. Tye
3. S. Lammel
4. Anthony A. Grace
5. Garret D. Stuber
6. B. Lim
7. Karl Deisseroth
8. R. Wise

Citations in the corpus

• Labelling and optical erasure of synaptic memory traces in the motor cortex (2015, background): “(2) Dendritic targeting element (DTE): the essential domains of AS-PaRac1 are the N-terminal PSD-95 (PSDΔ1.”
• Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens (2012, positive): “To explore if vHipp input encodes neutral contextual information or rather the incentive properties of the environment, we examined if optical activation of vHipp axons in the NAc could bias where mice spent their time in a three-room chamber (Tye and Deisseroth, 2012).”
• Dopamine System Dysregulation in Major Depressive Disorders (2017, background): “Recently, more evidence implicating the activity of the DA system has emerged using animal models of depression (Belujon and Grace, 2014; Tye and Deisseroth, 2012; Chaudhury et al., 2013; Savitz et al., 2013; Chang and Grace, 2014; Moreines et al., 2016).”
• Reward and aversion in a heterogeneous midbrain dopamine system (2013, methodology): “…in vivo and this work has provided important information, with the advent of optogenetics and novel viral tracing strategies (Osakada et al., 2011; Tye and Deisseroth, 2012), it is now possible to determine the anatomical connectivity of specific inputs unequivocally and address their putative…”
• Dopamine neurons modulate neural encoding and expression of depression-related behaviour (2012, background): “The heterogeneity of mood disorders further complicates the pinpointing of precise circuit dysfunctions mediating symptoms of depression 30 .”