Host cyclooxygenase-2 modulates carcinoma growth.
By C. Williams, M. Tsujii, J. Reese, S. Dey, R. Dubois. Journal of Clinical Investigation, 2000
708 citations recorded by the source corpus.
Subfields: Genetics, Pharmacology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/fd28bbfdb4efdbe90810722ef7987831bc236845
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Citations in the corpus
- Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (2004, background): “In both benign and malignant mouse intestinal tumours, stromal expression of cyclooxygenase-2 (COX2) results in elevated prostaglandin E 2 (PGE 2 ) levels, which in turn stimulate expression of the cell-surface prostaglandin receptor EP 2 , followed by induction of VEGF and angiogenesi”
- Hallmarks of cancer: interactions with the tumor stroma. (2010, background): “[26] C.”
- Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 (2001, background): “There is also genetic evidence implicating a role for host COX-2 in carcinoma growt”
- Fibroblast heterogeneity in the cancer wound (2014, background): “Wilson et al. (2012) made it clear that because of redundancy and overlap in many RTK signaling pathways, otherwise kinase-addicted neoplastic cells that respond to certain RTK inhibitors can be rescued from drug sensitivity simply by adding one or more RTK ligands.”
- The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. (2009, background): “, stromal cells) in the tumour microenvironment [100,113].”
- Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice (2001, background): “COX-2 in tumor tissues has been implicated in angiogenesis because vascularization decreases in tumors transplanted into COX-2–deficient mic”
- Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma (2005, methodology): “Furthermore, no major changes in COX-2 expression were observed in tumors excised from wild-type and COX-2 knockout mice, as previously described (19).”
- Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004, background): “…has recently extended these findings and showed that tumor angiogenesis and growth of explanted tumors are reduced in the COX-2 null mice; suggesting that host COX-2 induction by the tumor cells contributes to tumor angiogenesis and ultimately the growth of the tumors (Williams et al., 2000a).”