Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

By Rajnish A. Gupta, R. Dubois. Nature Reviews. Cancer, 2001

1,132 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Pharmacology

View Paper: https://www.semanticscholar.org/paper/efa6de393ee0b26e23cf4fe1acd160e7251f4098

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. Karin
2. S. Grivennikov
3. F. Greten
4. C. Harris
5. J. Gutkind
6. R. Dorsam
7. N. Perkins
8. Bharat B. Aggarwal

In Genetics

1. M. Karin
2. C. Harris
3. F. Greten

In Pharmacology

1. M. Karin
2. C. Harris

Citations in the corpus

• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “ety of prostaglandin synthases that catalyze the formation of prostaglandins and other eicosanoids (122).”
• Immunity, Inflammation, and Cancer (2010, background): “Despite such limitations, several anti-inflammatory drugs have been found to reduce tumor incidence when used as prophylactics, as well as to slow down progression and reduce mortality when used as therapeutics, particularly in the case of sporadic colon cancer (Gupta and Dubois, 2001).”
• Chronic inflammation and oxidative stress in human carcinogenesis (2007, background): “COX-2 is known to be involved in cancer biology, and it is upregulated in many cancer types including carcinomas of the colon, breast, lung, pancreas, esophagus, and head and neck.(27,28)”
• Natural forms of vitamin E: metabolism, antioxidant and anti-inflammatory activities and the role in disease prevention and therapy (2014, neutral): “Eicosanoids from COXs and 5-LOX pathways are recognized to contribute to cancer development [79,80,117,118].”
• Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. (2002, background): “Epidemiological studies indicate that the use of NSAIDs(4) is associated with a reduced risk of malignancies in the digestive tract (1).”
• G-protein-coupled receptors and cancer (2007, background): “For example, COX2 inhibition reduces the overall number and size of adenomas in patients who harbour germline mutations in the adenomatous polyposis coli ( APC ) tumour-suppressor gene, who are prone to developing colorectal cance”
• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut (2009, background): “…the cyclooxygenase activity of prostaglandin H synthases (PGHS, COX), which are rate-limiting for production of prostaglandin E2, a short-range lipid signal that promotes inflammation, wound healing, cell invasion, angiogenesis, and proliferation (Cha and DuBois, 2007; Gupta and Dubois, 2001).”
• Radical causes of cancer (2003, background): “cgi?l=5743">COX2 ), many studies focused on the latter, inducible isoform (COX2) as a crucial molecule in inflammatory-mediated carcinogenesi”