Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

By D. Simmons, R. Botting, T. Hla. Pharmacological Reviews, 2004

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Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “Next, it reduces PGG2 by its peroxidase activity to an endoperoxide, PGH2(266).”
Therapeutic potential of resveratrol: the in vivo evidence (2006, background): “The cyclooxygenase enzymes are crucial in the production of pro-inflammatory molecules by both the cyclooxygenase and 5-lipoxygenase pathways (for a review, see Ref”
Eight-carbon volatiles in mushrooms and fungi: properties, analysis, and biosynthesis (2006, background): “They have a major role in the immune response of higher organisms: prostaglandins are involved in inflammation, and thromboxanes induce platelet aggregation at the onset of blood clot formation (Brash 1999; Smith et al. 2000; Simmons et al. 2004).”
Selective COX-1 inhibition: A therapeutic target to be reconsidered. (2010, background): “In the last years, two isoforms of COX produced from different genes have been identified, COX-1 and COX2 [2].”