The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.

By A. Greenhough, H. Smartt, A. E. Moore, Heather R. Roberts, A. Williams, C. Paraskeva, Abderrahmane Kaidi. Carcinogenesis, 2009

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Differential Macrophage Programming in the Tumor Microenvironment (2012, neutral): “Whether this repolarization is important for therapeutic efficacy of COX-2 inhibitors is unknown however, as PGE2 has pleiotropic effects on multiple aspects of tumor development [108].”
Anti-Inflammatory Action and Mechanisms of Resveratrol (2021, background): “Prostanoids produced via COX-1 exert renal homeostasis, cytoprotective, immunomodulatory, and platelet function [56], while those derived from COX-2 participates in the inflammatory response [57].”
Cyclooxygenase‐2 in cancer: A review (2018, background): “(5) Maintenance of cancer stem cell (CSC)‐like activity via activation of WNT/β‐catenin/TCF (Greenhough et al., 2009) and miR526b (Majumder et al., 2015), and suppression of dual specificity phosphatase 2 (Hou et al., 2017).”