Glutamate excitotoxicity in a model of multiple sclerosis

By D. Pitt, P. Werner, C. Raine. Nature Medicine, 2000

890 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/fc8b784f2620db5ce1c872d6c588d94080363aaa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Fred H. Gage
2. Sebastian Jessberger
3. Gregory D. Clemenson
4. N. Toni
5. J. Ray
6. Roland Martin
7. M. Sospedra
8. F. Quintana

In Molecular Biology

1. J. Ray
2. Roland Martin
3. M. Sospedra
4. Naftali Kaminski
5. Fred H. Gage
6. Sebastian Jessberger
7. S. Galli
8. Michael A. Wheeler

In Pathology and Forensic Medicine

1. Roland Martin
2. M. Sospedra
3. Paul Klonowski
4. Jorge R. Oksenberg
5. C. Iadecola
6. J. Buckner

Citations in the corpus

• Directed differentiation of hippocampal stem/progenitor cells in the adult brain (2008, background): “This finding has potential clinical relevance, as many neurological diseases, such as multiple sclerosis, stroke and epilepsy, not only affect neuronal cells, but also disrupt the functioning of other neural cell types, such as oligodendrocyte”
• Multiple sclerosis: a complicated picture of autoimmunity (2007, background): “Treatment of mice with EAE with an antagonist to the receptor for the excitatory transmitter glutamate reduces clinical disease and increases axon and oligodendrocyte surviva”
• Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis (2002, background): “An NMDA antagonist has been shown to reduce severity of EAE (ref”
• The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy (2004, background): “In one of these studies [58],mice acquired EAE after transfer of lymph node cells sensitized to myelin basic protein.”
• Astrocyte crosstalk in CNS inflammation (2020, background): “Other roles of astrocytes in excitotoxicity include the reduced expression of the glutamate uptake transporters GLAST and GLT-1 in models of neuroinflammation (Pitt et al., 2000), AD (Matos et al.”
• New concepts in the immunopathogenesis of multiple sclerosis (2002, neutral): “Although most of the damage is a direct result of the coordinated immune attack that is mediated through specific cellular and humoral mechanisms, nonspecific immune mediators, neurotransmitters and toxic substances (such as nitric oxide) might significantly facilitate this proces”