Directed differentiation of hippocampal stem/progenitor cells in the adult brain

By Sebastian Jessberger, N. Toni, Gregory D. Clemenson, J. Ray, Fred H. Gage. 2008

257 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Review retroviral-mediated Mash1/Ascl1 expression redirects neurogenic intermediate progenitors to an exclusive oligodendocyte lineage in the adult SGZ (Jessberger et al., 2008).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, methodology): “Viruses were produced as described previously (38).”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Table 1 Signals regulating adult hippocampal neurogenesis Stages Regulators Secreted factors and downstream effectors (Morphogens, growth fa”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “Overexpression of Mash1 (also known as Ascl1) in adult hippocampal cells redirects differentiation of these postnatal progenitors from neuronal production to oligodendrocyte production (Jessberger et al. 2008).”
Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination (2010, unknown): “A recent study found that hippocampal NPCs change their fate potential to generate oligodendrocytes, rather than neurons, after retroviral-mediated overexpression of the bHLH transcription factor Ascl1 (Mash1”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, unknown): “…vectors CAG-GFP (cytomegalovirus immediate early enhancer-chicken -actin hybridgreen fluorescent protein) (Zhao et al., 2006), CAG-RFP (red fluorescent protein) (Tashiro et al., 2006b), CAG-IRES (internal ribosomal entry site)-GFP (Jessberger et al., 2008), and short hairpin (sh) RNA-Na -”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, unknown): “However, such approach has been shown to be effective in affecting the fate choice of adult neural progenitors in vivo (Jessberger et al., 2008).”
Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis (2010, background): “commonly used as a specific marker for these cells [15,19].”
Structural Plasticity and Hippocampal Function (2010, background): “In addition, the regulation of adult neurogenesis by specific genes can be studied by engineering viral vectors to induce specific types of genetic manipulations (Ge et al. 2006, Jessberger et al. 2008b, Tashiro et al. 2006).”
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine SVZ-neuronal progenitors via cell autonomous mechanisms involving Notch signaling (2010, background): “, 2005; Jiao and Chen, 2008) and that differences in the microenvironment and signaling pathways govern the two adult neurogenic niches (Alvarez-Buylla and Lim, 2004; Jessberger et al., 2008; Moyse et al., 2008).”