Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.

By A. Towarowski, A. Krug, S. Britsch, S. Rothenfusser, V. Hornung, R. Bals, T. Giese, H. Engelmann, S. Endres, A. Krieg and 1 more. European Journal of Immunology, 2001

632 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/fc5e80ed0a61b71ca7174a25ca6aaa4157c923c2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. Satoshi Uematsu
3. R. Medzhitov
4. K. Takeda
5. Yong‐jun Liu
6. R. Steinman
7. T. Kaisho
8. A. Krieg

In Microbiology

1. Shizuo Akira
2. K. Takeda
3. Yong‐jun Liu
4. Satoshi Uematsu
5. M. Kapsenberg
6. A. J. Dawson
7. A. Panoskaltsis‐Mortari
8. B. Blazar

Citations in the corpus

• The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo (2002, background): “This may allow subsets of DCs to present select antigens and microbes; in addition these subsets can express distinct toll-like receptors (46, 47).”
• Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 (2004, background): “on myeloid DCs (19, 20), thus, human PDCs but not myeloid DCs”
• Immune surveillance in the skin: mechanisms and clinical consequences (2004, background): “TLR expression is variable and might identify subsets of innate immune cells, such as DCs, with specific function”
• Toll-like receptors. (2003, background): “Expression of TLRs in dendritic cells differs among their subsets (124, 140).”
• Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 (2005, background): “TLR expression of human PDC is limited to TLR7 and TLR9 (refs”
• Photodynamic therapy and anti-tumour immunity (2006, background): “So far, 13 TLR family members have been identified on monocytes and macrophages, dendritic cells, mast cells and some epithelial cell”
• Dendritic-cell control of pathogen-driven T-cell polarization (2003, background): “cgi?l=959">CD40L , which is rapidly expressed by the T cells after their activation by the DC-derived signals 1 and 2 (Ref”
• Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1 (2002, background): “In earlier studies we and others demonstrated by using semiquantitative RT-PCR that PDC express TLR9, while monocytes expressed TLR2 and TLR4 (6, 9).”