Immune surveillance in the skin: mechanisms and clinical consequences

By T. Kupper, R. Fuhlbrigge. Nature reviews. Immunology, 2004

840 citations recorded by the source corpus.

The skin, as the primary interface between the body and the environment, provides the first line of defence against a broad array of microbial pathogens and trauma. In addition to its properties as a physical barrier, the skin has many active defence mechanisms. In this review, we discuss the interaction between the innate and adaptive immune systems in the skin as a model for immune function at epithelial-cell interfaces with the environment. How these mechanisms account for the robust nature of cutaneous immune surveillance and how their dysregulation drives the pathogenesis of inflammatory skin disorders and skin-based tumours are the subjects of this review.

Subfields: Dermatology, Immunology

View Paper: https://www.semanticscholar.org/paper/01dc73bfeea1af0b817997efa253a25a1a8613a6

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Citations in the corpus

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, background): “In particular, T cells recirculating selectively through the skin express cutaneous lymphocyte-associated antigen (CLA) and the chemokine receptors CCR4 and CCR10, whereas T cells homing to the small intestine express integrin α 4 β 7 and CCR9 (refs”
An Overview of the Immunological Defenses in Fish Skin (2012, background): “In humans, the immune system of the skin (skin immune system (SIS) or skin-associated lymphoid tissue (SALT)) is an independent organ-specific manifestation in contrast to the immune system of other organ systems [236].”
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production (2005, background): “Because injury to the skin is a well known elicitation factor for psoriasis (42), PDC activation may result from the release of skin-derived products on infectious or mechanical stress (simulated in the AGR / model by the transplantation procedure).”
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Skin Acute Wound Healing: A Comprehensive Review (2019, background): “The dermis has the skin appendages, mast cells, fibroblasts, antigen presenting dermal cells, resident and circulating immune cells [4].”
Microneedles for drug and vaccine delivery (2012, background): “Clinical experience with hypodermic needles suggests that residual holes left by sterile needles is not a significant source of infection [341], in large part because the skin has a host of pathogen defense mechanisms to protect it from infection [342].”
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 (2007, background): “In the context of physiological immune responses, T cells respond to antigens presented by antigen-presenting DCs in extralymphoid tissues such as the ski”
Skin immune sentinels in health and disease (2009, background): “Initial views of skin immunosurveillance emphasized the importance of immune cells that circulate between skin-draining lymph nodes and peripheral tissue and that can react quickly to antigen challenge”