Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

By V. Hornung, M. Guenthner-Biller, C. Bourquin, A. Ablasser, M. Schlee, Satoshi Uematsu, A. Noronha, M. Manoharan, Shizuo Akira, A. D. Fougerolles and 2 more. Nature Medicine, 2005

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RNAi therapeutics: principles, prospects and challenges. (2007, background): “Yet, last year a key publication demonstrated that certain siRNA sequence motifs invoked TLR7-dependent immune stimulation [54].”
Current prospects for RNA interference-based therapies (2011, background): “This finding also opened investigators' eyes to the possibility of purposefully using immunostimulatory RNAi as a direct therapeutic or adjuvant 9 .”
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates (2008, background): “Certain siRNAs can induce immune responses via interferons and proinflammatory cytokines (9, 10).”
Intracellular toll-like receptors. (2010, neutral): “Finally, TLR7may recognize some siRNAs (Hornung et al., 2005).”