Identification of hundreds of conserved and nonconserved human microRNAs

By Isaac Bentwich, A. Avniel, Yael Karov, Ranit Aharonov, S. Gilad, Omer Barad, Adi Barzilai, P. Einat, Uri Einav, E. Meiri and 3 more. Nature Genetics, 2005

1,941 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fab842f40e3ad94396aa89b578d2e0920032d55e

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Citations in the corpus

Serum MicroRNAs Are Promising Novel Biomarkers (2008, background): “We measured the serum levels of 28 microRNAs, including microRNAs reported to be placenta-specific [10,20] as well as broadly expressed microRNAs.”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “With the latest human miRNA count swelling to over 800, miRNAs easily account for >3% of all human genes (Bentwich et al. 2005).”
MicroRNAS and their regulatory roles in plants. (2006, background): “With the exception of the miR-430 family, which is represented by a cluster of ∼80 loci in zebrafish (42), and a related family, which is represented by a cluster of 43 loci in human (18), animal miRNAs typically fall into smaller families that have much more diverse members; metazoan family members”
Genomics of microRNA. (2006, methodology): “A more informative but complicated method uses a biotinlabeled oligonucleotide to capture miRNA from a cDNA library, which is then amplified by PCR using adaptor primers [ 21 ].”
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. (2006, methodology): “Our approach to detect viral miRNAs is very similar to the one developed independently by Bentwich et al. (2005) for the identification of cellular miRNAs.”
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. (2010, background): “2005), microarrays (Bentwich et al. 2005), and RNA-primed array-based Klenow extension (RAKE) (Berezikov et al.”
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis (2008, background): “However, miR-373 has not been implicated in tumour metastasis; miR-520c was discovered recently by sequencing of cellular miRNA”
The Genetic Signatures of Noncoding RNAs (2009, background): “Many miRNAs are highly conserved from nematodes to humans, whereas others are primate-specific, and their full repertoire remains to be determined [4,69,70].”
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. (2007, methodology): “Several protocols even explicitly evaluate the distance between the predicted miRNA and miRNA* as a characteristic feature of miRNA hairpins (Bentwich et al. 2005), again including the approach described here.”