The diverse and complex roles of NF-κB subunits in cancer

By N. Perkins. Nature Reviews. Cancer, 2012

801 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fa652d24766e130f2dd1af8209fa84ecabe4dd60

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Immunology

Citations in the corpus

Oxidative Stress in Cancer (2020, background): “Constitutive activation of NF-κB is observed in many cancers, where it promotes the survival, proliferation, and metastasis of tumor cells by increasing expression of anti-apoptotic genes, cyclins, MMPs, cell adhesion genes, and pro-angiogenic genes (Perkins, 2012).”
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. (2018, neutral): “…of cytokines, such as CCL18 and IL-1b, in the tumor microenvironment may be responsible for initiating the NF-kB signaling by activating IKK in the CAF subset (Erez et al., 2010; Su et al., 2014), IKK activation is usually not sustainable due to numerous negative feedback loops (Perkins, 2012).”
30 years of NF-κB: a blossoming of relevance to human pathobiology (2017, positive): “Furthermore, upregulated NF-κB promotes cell proliferation, metastasis, metabolic changes and other abnormalities that favor the expansion and spread of malignancy (Kim et al., 2006; Perkins, 2012).”
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. (2013, background): “Oncogenic K-ras strongly cooperates with deregulated Wnt signaling conferred by Apc loss or activating Ctnnb mutations (Bennecke et al., 2010; Janssen et al., 2006; Sansom et al., 2006), although it can also induce NF-kB activation (Perkins, 2012).”
The complexity of NF-κB signaling in inflammation and cancer (2013, background): “Several of these links have been studied and characterized in more detail, in particular those with STAT family members (signal transducers and activators of transcription) and with the p53 tumor suppressor [107,108].”