CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.

By Shicheng Su, Jianing Chen, H. Yao, Jiang Liu, Shubin Yu, Liyan Lao, Minghui Wang, Manli Luo, Yue Xing, Fei Chen and 8 more. Cell, 2018

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Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. (2020, background): “It is now recognized that CAF are heterogenous and that distinct CAF subsets can be defined based on expression of specific markers (7-17).”
IL-1-induced JAK/STAT signaling is antagonized by TGF-β to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. (2018, background): “We hypothesized that NF-κB signaling might play a role in iCAF formation, as it has been previously identified as a pathway responsible for the induction of an inflammatory profile in CAFs (25,26).”