30 years of NF-κB: a blossoming of relevance to human pathobiology

By Qian Zhang, M. Lenardo, David Baltimore. Cell, 2017

1,766 citations recorded by the source corpus.

NF-κB was discovered thirty years ago as a rapidly inducible transcription factor. Since that time it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ddf0fd675594849750bf4d4f52cdbd535e937b18

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In Cancer Research

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Citations in the corpus

• NF-κB in Oxidative Stress (2017, background): “Active NF-kB then translocates into the nucleus and activates the target genes [4].”
• Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “As a ubiquitous transcription factor, NF-κB consists of five different proteins: RelA (p65), RelB, c-Rel, NF-κB1 (p50), and NF-κB2 (p52).(278) Generally, core components of NF-κB signaling pathway are inhibitors of NF-κB (IκB) proteins, namely, the IκB kinase (IKK) complex and NF-κB transcription fa”
• Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “Being discovered in 1986, the nuclear factor κB (NF-κB) is an important transcription factor in the human body, and is involved in cell survival, oxidative damage, inflammation, immune responses, and angiogenesis.(258,259) As an indirect mediator, NF-κB regulates the development of various carcinoma”
• The JAK/STAT signaling pathway: from bench to clinic (2021, background): “NF-κB regulates a large variety of cellular responses, especially throughout the immune system.(196) The cross-talk between the JAK/STAT signaling pathway components and the NF-κB signaling pathway components is extensive.”