The complexity of NF-κB signaling in inflammation and cancer
By Bastian Hoesel, Johannes A. Schmid. Molecular Cancer, 2013
2,915 citations recorded by the source corpus.
The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of cancer initiation and progression. During these latter processes NF-κB cooperates with multiple other signaling molecules and pathways. Prominent nodes of crosstalk are mediated by other transcription factors such as STAT3 and p53 or the ETS related gene ERG. These transcription factors either directly interact with NF-κB subunits or affect NF-κB target genes. Crosstalk can also occur through different kinases, such as GSK3-β, p38, or PI3K, which modulate NF-κB transcriptional activity or affect upstream signaling pathways. Other classes of molecules that act as nodes of crosstalk are reactive oxygen species and miRNAs. In this review, we provide an overview of the most relevant modes of crosstalk and cooperativity between NF-κB and other signaling molecules during inflammation and cancer.
Subfields: Cancer Research, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/518b5578fa84f9434831cacb3fb0adca72fb66dc
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Citations in the corpus
- Anti-Inflammatory Action and Mechanisms of Resveratrol (2021, background): “Recently, it has become very clear that there are two separate NF-κB activation pathways: the classical pathway and the alternative pathway [76,77].”
- Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? (2016, neutral): “There are no competing interests to declare.”
- Targeting cancer stem cell pathways for cancer therapy (2020, background): “[275] [276] [277] The primary mode of NF-κB regulation occurs at the level of subcellular localization.”
- Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis (2019, background): “The NF-κB protein family is widely involve in inflammation, stress response, survival, and cell death [65].”
- Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “Generally, core components of NF-κB signaling pathway are inhibitors of NF-κB (IκB) proteins, namely, the IκB kinase (IKK) complex and NF-κB transcription factor.(279,280) In the canonical NFκB pathway, activation is triggered by the binding of ligands (e.”