Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

By C. Rousseaux, X. Thuru, A. Gelot, N. Barnich, C. Neut, L. Dubuquoy, C. Dubuquoy, E. Mérour, K. Geboes, M. Chamaillard and 6 more. Nature Medicine, 2007

784 citations recorded by the source corpus.

Subfields: Gastroenterology, Pharmacy, Physiology

View Paper: https://www.semanticscholar.org/paper/f9f8de759c71bc6d6d074b00a35f606c8e660a03

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. Emeran A. Mayer
5. S. Mazmanian
6. C. Stanton
7. Yan Wang
8. L. Kasper

In Pharmacy

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. C. Stanton
6. Yan Wang
7. L. Kasper
8. S. Grenham

In Physiology

1. J. Cryan
2. Patrice D Cani
3. Ted G. Dinan
4. Rob Knight
5. F. Bäckhed
6. G. Clarke
7. N. Delzenne
8. Yan Wang

Citations in the corpus

• Probiotics and the gut microbiota in intestinal health and disease (2010, background): “A study conducted in a mouse model of chronic colonic hypersensitivity describes modulation of the murine microflora with Lactobacillus acidophilus , strain NCMF, to induce opioid and cannabinoid receptor expression on intestinal epithelial cells and restore normal perception of visceral pain”
• Intestinal microbiota in functional bowel disorders: a Rome foundation report (2012, background): “Lactobacillus acidophilus NCFM and Lactobacillus paracasei NCC2461 also modulate visceral pain perception in rodents.(60) 61 Transient perturbation of the microbiota with antimicrobials alters brain-derived neurotrophic factor expression, exploratory behaviour and colonisation of germfree mice sugge”
• Brain–Gut–Microbe Communication in Health and Disease (2011, background): “, 2010), with, for example, one study demonstrating that specific Lactobacillus strains could induce the expression of μ-opioid and cannabinoid receptors in intestinal epithelial cells and mimic the effects of morphine in promoting analgesia (Rousseaux et al., 2007).”
• The endocannabinoid system links gut microbiota to adipogenesis (2010, background): “It is noteworthy that the lack of effect on CB2 expression observed in our study could merely be explained by the fact that Rousseaux et al (2007) used a specific strain and did not investigate the modulation of gut microbiota.”
• Effects of Probiotics, Prebiotics, and Synbiotics on Human Health (2017, background): “Studies on animals demonstrated that orally administered Lactobacillus acidophilus induces expression of μ-opioid and cannabinoid receptors in intestinal cells and mediate analgesic functions in the intestine, and that the observed effect is comparable to the effect of morphine [82].”
• Gut Microbes and the Brain: Paradigm Shift in Neuroscience (2014, background): “Probiotic treatment has also proved efficacious in alleviating visceral pain responses in animal models (Rousseaux et al., 2007; McKernan et al., 2010).”
• Psychobiotics: a novel class of psychotropic. (2013, background): “lates expression of cannabinoid receptors in the spinal cord (17).”
• Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve (2011, background): “Indeed, visceral perception in rodents can be affected by alterations in gut microbiota (5).”