The endocannabinoid system links gut microbiota to adipogenesis

By G. Muccioli, D. Naslain, F. Bäckhed, Christopher S. Reigstad, D. Lambert, N. Delzenne, Patrice D Cani. Molecular Systems Biology, 2010

673 citations recorded by the source corpus.

Obesity is characterised by altered gut microbiota, low‐grade inflammation and increased endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota and eCB signalling has yet to be confirmed. Here, we report that gut microbiota modulate the intestinal eCB system tone, which in turn regulates gut permeability and plasma lipopolysaccharide (LPS) levels. The impact of the increased plasma LPS levels and eCB system tone found in obesity on adipose tissue metabolism (e.g. differentiation and lipogenesis) remains unknown. By interfering with the eCB system using CB1 agonist and antagonist in lean and obese mouse models, we found that the eCB system controls gut permeability and adipogenesis. We also show that LPS acts as a master switch to control adipose tissue metabolism both in vivo and ex vivo by blocking cannabinoid‐driven adipogenesis. These data indicate that gut microbiota determine adipose tissue physiology through LPS‐eCB system regulatory loops and may have critical functions in adipose tissue plasticity during obesity.

Subfields: Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/8ec3f8674ba89224eaec8b50f5fd8f1047f7faa8

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Citations in the corpus

Effects of Gut Microbes on Nutrient Absorption and Energy Regulation (2012, background): “A recent report suggests that these effects may be mediated, at least in part, by interactions between LPS and adipose tissue metabolism through endocannabinoid-driven adipogenesis.(107) The innate immune system also appears to play a role in both regulating the gut microbiota and, by extension,”
The human gut microbiota: Metabolism and perspective in obesity (2018, background): “The best characterized of these lipids are anandamide (AEA) and 2-arachidonoylglycerol (2-AG),(46) which activate receptors coupled to G, CB1, and CB2 proteins, thus activating the PPARa, GPR55, and GPR119 receptors.(47) The modulation of the gut microbiota or the reduction of CB1 activation improve”
Psychobiotics: a novel class of psychotropic. (2013, background): “The endocannabinoid system and the gut microbiota can impact on the development of obesity and related disorders (16).”
Gut Microbiome: Profound Implications for Diet and Disease (2019, methodology): “A study of the eCB system in lean and obese mice was performed by blocking or activating cannabinoid receptor 1 (CB1) [279].”
Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity (2012, background): “We proposed that selective changes in the gut microbiota of obese mice impact LPS levels, a process that may participate in adipogenesis regulation.(37) Based on a recent study from our lab,(24) we suggest that the impact of gut microbiota modulation on adipose tissue metabolism can be mediated by t”
Human Intestinal Barrier Function in Health and Disease (2016, background): “Muccioli et al.(93) showed that the gut microbiota can also regulate gut permeability via the endocannabinoid system, the”
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity (2013, background): “However, we cannot exclude the possibility that the improvements in glucose and lipid metabolism occurred via an LPS-dependent mechanism, as demonstrated previously (5, 7).”
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review (2023, background): “…Muccioli et al. demonstrated that blockage of the cannabinoid receptor-1 using CB1 antagonists lowered gut permeability and adipogenesis in obese mice, through normalizing Occludin and ZO-1 expression, whereas CB1 stimulation increased permeability markers both in vivo and in vitro [27].”
Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice (2011, methodology): “with prebiotics, such as oligofructose (Ob-Pre) (Orafti, Tienen, Belgium) for 5 weeks as previously described (8,15).”
Gut microbiome and health: mechanistic insights (2022, background): “108 It began with the finding that the intestinal eCB system is altered during obesity and diabetes, with an increased abundance of AEA that triggers gut permeability via CB 1 - dependent mechanisms.”