Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

By J. Bravo, P. Forsythe, Marianne V Chew, Emily Escaravage, H. Savignac, Ted G. Dinan, J. Bienenstock, J. Cryan. Proceedings of the National Academy of Sciences of the United States of America, 2011

3,643 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Molecular Biology, Pharmacy

View Paper: https://www.semanticscholar.org/paper/56a28e9025420bb1919a4aaa72544ab42623963e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. J. Foster
5. L. Rinaman
6. P. Kennedy
7. C. Stanton
8. S. Mazmanian

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. Yan Wang
5. L. Kasper
6. S. Mazmanian
7. C. Stanton
8. T. Sampson

In Pharmacy

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. C. Stanton
6. T. Sampson
7. P. Kennedy
8. R. Stilling

Citations in the corpus

• The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Behavior Human and mice brain function (Heijtz et al. 2011; Bravo et al. 2011; Morgan and Curan 1991; Sudo et al. 2004; Neufeld et al. 2011)”
• Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “On the contrary, another report indicates that vagotomized mice treated with Lactobacillus rhamnosus show minimal improvement in anxiety- and depression-related behaviors, with no change in the expression of GABA receptors in brain [108].”
• Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “…et al., 2001), cannabinoids (Hill and Gorzalka, 2009), altering the intestinal microflora (Ma et al., 2004, Karimi et al., 2009) (Rhee et al., 2009, Bravo et al., 2011), minocycline (Plane et al., 2010) (Molina-Hernandez et al., 2008, Pae et al., 2008) which potentially reduces inflammatory…”
• Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study (2017, background): “, 4-ethylphenylsulfate, indolepyruvate, and corticosterone) that affect GI function and neurobiological conditions, such as ASD and anxiety [9, 10].”
• Dysbiosis of the gut microbiota in disease (2015, background): “Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression (76).”
• Gut microbiota are related to Parkinson's disease and clinical phenotype (2015, background): “The vagal nerve is also crucial for the communication between gut microbiota and the brain, and microbiota influence the activity of vagal afferents.(59,60) These observations demonstrate a pathway through which gut microbiota could be related to ENS and CNS neuropathology in early PD.”
• Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders (2021, background): “Administration with probiotics such as Lactobacillus rhamnosus can regulate the mRNA levels of GABAB1b and GABAAα2 subunits in distinct regions of the brain including the cortex, the hippocampus, and the amygdala, thereby ameliorating anxiety- and depression-like behaviors in mice [75].”