Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

By E. McDonald, Antoine de Weck, M. Schlabach, E. Billy, Konstantinos J. Mavrakis, G. Hoffman, Dhiren Belur, D. Castelletti, Elizabeth Frias, Kalyani Gampa and 90 more. Cell, 2017

599 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/92b8100aa3ba435428b570b454facd1a0a03671e

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In Molecular Biology

Citations in the corpus

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. (2018, methodology): “Numerous reports have observed heterogeneous dependence for sustained KRAS expression (<50% addicted) across KRASmutant cancer cell lines (Hayes et al., 2016; Kapoor et al., 2014; Lamba et al., 2014; Patricelli et al., 2016; Shao et al., 2014; Singh et al., 2009; Sunaga et al., 2011; Vartanian et al”
Proteolysis Targeting Chimeras as Therapeutics and Tools for Biological Discovery (2020, unknown): “Interestingly, both this work and a concurrent study from Boehringer Ingelheim (Popow et al., 2019) failed to phenocopy the antiproliferative effect of short hairpin RNA (shRNA)-mediated FAK depletion (McDonald et al., 2017).”
Quantitative Proteomics of the Cancer Cell Line Encyclopedia (2020, methodology): “Within the DRIVE data there were several genes where sensitivity to knockdown was associated with at least half the members of a protein complex (Figure 7A).”
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens (2019, unknown): “4d), with similar false discovery rates for putative context-specific fitness genes (taken from(McDonald et al. 2017), Extended Data Fig.”