Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy.

By A. Sica, T. Schioppa, A. Mantovani, P. Allavena. European Journal of Cancer, 2006

1,485 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/f9d8009e00258f581fd25efc4d53f4c1ac10cc11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. J. Campisi
5. C. Garlanda
6. L. Chávez-Galán
7. I. Garcia
8. D. Vesin

In Molecular Biology

1. J. Campisi
2. T. Hirano
3. J. Talmadge
4. I. J. Fidler
5. P. Desprez
6. Jean-Philippe Coppé
7. A. Sica
8. L. Chávez-Galán

In Oncology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. C. Garlanda
5. L. Chávez-Galán
6. I. Garcia
7. D. Vesin
8. Maria L. Olleros

Citations in the corpus

• IL-6 in inflammation, autoimmunity and cancer (2020, background): “The requirement for human naive T cells in T h 17 cell differentiation differs from that of mice, since human T cells in the presence of IL-1 β with IL-6 or IL-23 can differentiate to T h 17 cells without TGF β (169, 170).”
• AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective (2010, positive): “sponses (164), in addition to facilitating tumor proliferation and metastasis (165) via pro-angiogenic activity.”
• The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients (2012, background): “TAMs, which are often abundantly present in malignant tumors, share many common features with the alternatively activated antiinflammatory macrophages (M2) [2].”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “For their phenotypic and functional properties TAM resemble M2-polarized macrophages, though there are some distinctive features [58,59].”
• Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury (2011, background): “M2 cells release anti-inflammatory cytokines and protect surrounding cells, promoting angiogenesis and healing at later stages of recovery [158].”
• Senescent cells as a source of inflammatory factors for tumor progression (2010, background): “Molecules that are implicated in the recruitment and differentiation of circulating monocytes to tumor sites also happen to be overexpressed by senescent fibroblasts [137].”
• Stromal gene expression predicts clinical outcome in breast cancer (2008, background): “Monocytes and TAMs accumulate in hypoxic areas of tumors, in part recruited by the action of chemoattractants such as CXCL1 and ET-1 induced in the hypoxic environmen”
• Integrative Clinical Genomics of Metastatic Cancer (2017, neutral): “While immunosuppressive M2 macrophages 36 were highly prevalent, pro-inflammatory, anti-tumor M1 macrophages were largely absent.”
• Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord (2009, background): “M2 macrophages promote angiogenesis and matrix remodeling while suppressing destructive immunity (Sica et al., 2006).”
• Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. (2010, background): “It has been suggested that TAMs display an M2-like phenotype (8), although it is not clear whether these findings can be generalized and are applicable to TAMs in different tumor regions.”
• Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, methodology): “We thank the fellowship for LCG (207760), provided by the Consejo Nacional de Ciencia y Tecnología (CONACyT), Mexico, and the FNS (31-46833) and the Ligue Pulmonaire Genevoise.”