AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

By J. Talmadge, I. J. Fidler. Cancer Research, 2010

1,184 citations recorded by the source corpus.

Metastases resistant to therapy is the major cause of death from cancer. Despite almost 200 years of study, the process of tumor metastasis remains controversial. Stephen Paget initially identified the role of host-tumor interactions on the basis of a review of autopsy records. His “seed and soil” hypothesis was substantiated a century later with experimental studies and numerous reports have confirmed these seminal observations. Inarguably, an improved understanding of the metastatic process and the attributes of the cells selected by this process are critical to the treatment of patients with systemic disease. In many patients, metastasis has occurred by the time of diagnosis, such that metastasis prevention may not be relevant, and treatment of systemic disease, as well as the identity of patients with early disease, should be our goal. During the last three decades, revitalized research has focused on new discoveries in the biology of metastasis. While our understanding of the molecular events that regulate metastasis has improved; nonetheless, the relevant contributions and timing of molecular lesion(s) potentially involved in its pathogenesis remain unclear. The history of pioneering observations and discussion of current controversies should help investigators understand the complex and multifactorial interactions between the host and selected tumor cells that contribute to fatal metastasis and allow for the design of successful therapy.

Subfields: Biotechnology, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/5e2a7e673844f52704c0559c71e04b4202181db9

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In Biotechnology

1. J. P. Thiery

In Cancer Research

1. J. P. Thiery
2. Bert Vogelstein
3. Jormay Lim

In Oncology

1. Jormay Lim
2. J. P. Thiery
3. Bert Vogelstein
4. R. Weinberg
5. E. Hay
6. J. Massagué
7. Jing Yang
8. Raghu Kalluri

Citations in the corpus

• Epithelial-mesenchymal transitions: insights from development (2012, background): “Circulating carcinoma cells can extravasate and localize in the parenchyma of distant organs where they will resume growth to form metastatic tumors (Talmadge and Fidler, 2010).”
• Hallmarks of cancer: the next generation. (2011, neutral): “The multistep process of invasion and metastasis has been schematized as a sequence of discrete steps, often termed the invasion-metastasis cascade (Talmadge and Fidler, 2010; Fidler, 2003).”
• A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity (2015, background): “Though tumor cell migration has historically been viewed as a feature of cancer associated with late events in tumorigenesis, such as invasion through basement membranes or vascular walls, this classical view of migration pertains to the ability of cancer cells to migrate over large distances [36].”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “The dissemination of cancer cells from primary tumors and their subsequent seeding of new tumor colonies in distant tissues involves a multi-step process known as the invasionmetastasis cascade (Fidler, 2003; Gupta and Massague, 2006; Talmadge and Fidler, 2010).”
• Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “The late dissemination model is seemingly supported by the fact that a successful metastatic cell must dissociate from the primary tumor, invade the surrounding tissues and penetrate the local vasculature, survive within the circulation, and be immobilized in the capillaries of target tissues/organs”
• Apoptosis, autophagy, necroptosis, and cancer metastasis (2015, background): “Multiple cellular processes, including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiogenesis, the development of an inflammatory tumor microenvironment, and the dysfunction of programmed cell death machinery, have been demonstrated to b”