Stromal gene expression predicts clinical outcome in breast cancer

By Greg Finak, N. Bertos, F. Pépin, S. Sadekova, Margarita Souleimanova, Hong Zhao, Haiying Chen, Gulbeyaz Omeroglu, S. Meterissian, A. Omeroglu and 2 more. Nature Medicine, 2008

1,644 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/54b511d9114f25fe0020e66754d1c5beaeec8143

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In Molecular Biology

In Oncology

In Pulmonary and Respiratory Medicine

Citations in the corpus

Hallmarks of cancer: interactions with the tumor stroma. (2010, background): “Indeed, a stroma-derived gene expression signature prognostic of clinical outcome was described for breast carcinoma [37].”
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. (2009, background): “Moreover, a recent study has indicated that gene expression signatures within the stroma can be useful prognostic predictors of breast cancer progression (Finak et al., 2008).”
Identification of tumor epithelium and stroma in tissue microarrays using texture analysis (2012, methodology): “Stromal cells and their roles in cancer prognosis [8] and response-prediction [9] have been increasingly recognized.”
CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages (2009, background): “…profiling from breast-cancer-associated stroma revealed a gene signature predictive of good prognostic outcome (>98%, 5 year survival) that was functionally enriched for elements of a T H 1-type immune response, including genes suggestive of CTL and NK cell activity (Finak et al., 2008 ).”
Prognostic significance of the tumor-stroma ratio: validation study in node-negative premenopausal breast cancer patients from the EORTC perioperative chemotherapy (POP) trial (10854) (2013, background): “Other gene signatures in the stromal compartment have proven to be prognostic for breast cancer patient follow-up [17, 18].”
CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages (2015, background): “Previously, we showed that a chemokine CCL2 recruits IMs to metastatic sites where they differentiate to MAMs (Qian et al., 2011).”
Stroma Cells in Tumor Microenvironment and Breast Cancer (2012, positive): “[91] have developed a 26gene predictor (stroma-derived prognostic predictor) that predicts disease outcome with greater accuracy than predictors or signatures derived from whole tissue.”
G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “Such observations further support the concept that the complex interactions between cancer cells and stroma are attractive drug target”
Gene expression profiling of the tumor microenvironment during breast cancer progression (2009, background): “Molecular alterations within the stroma offer novel avenues for therapeutic interventions and disease prognosis [53].”