Faculty Opinions recommendation of CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.

By P. Roepe. 2006

595 citations recorded by the source corpus.

Subfields: Immunology, Obstetrics and Gynecology

View Paper: https://www.semanticscholar.org/paper/f9b9a122b7a3b75cfc6cd23b2e4704dddcdc29b5

Citations in the corpus

• Complement System Part I – Molecular Mechanisms of Activation and Regulation (2015, unknown): “immunoglobulin Superfamily Receptor CRig Immunoglobulin superfamily receptor CRIg is a CR expressed on macrophages and Kupffer cells in the liver that binds to C3b and iC3b (Figure 14) and mediates the phagocytosis of opsonized particles and pathogens (310, 311).”
• Complement - a key system for immune surveillance and homeostasis (2010, unknown): “CRIg is exclusively expressed on certain tissue-resident macrophages and enhances phagocytosis by recognizing cell-bound C3b and iC3”
• Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. (2014, unknown): “A lack of Kupffer cells or of their complement receptors results in uncontrolled bacteraemia and increased host death in experimental models [19].”
• The complement system: an unexpected role in synaptic pruning during development and disease. (2012, unknown): “In addition, the newly identified iC3b/C3 receptor immunoglobulin (Ig)-superfamily member CRig (Z39Ig, VSIG4), although not yet assessed in microglia, has been shown to mediate complement-mediated phagocytosis in subpopulations of resident tissue macrophages (Helmy et al. 2006, Gorgani et al. 2008).”
• Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, unknown): “They express low levels of CD11b, the type complement receptor, but express a unique Ig-complement receptor (CRIg) (89).”
• Para-inflammation in the aging retina. (2009, unknown): “6), a receptor only expressed by a subset of macrophages (Helmy et al., 2006).”
• NETosis: how vital is it? (2013, unknown): “Previous studies, prior to the discovery of NETs, attributed the capture of circulating bacteria exclusively to the liver sinusoidal macrophages, or Kupffer cells, via expression of the complement receptor CRIg.66 However, our data suggest that NET release increases total bacteria capture by three- ”
• Kupffer Cells in the Liver (2013, unknown): “More recently, Helmy et al. described CRIg as a complement receptor that is required for the clearance of circulating pathogens (41).”
• Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. (2012, unknown): “In contrast to neutrophils, Kupffer cells capture circulating bacteria upon their surface using unique receptors such as the complement receptor for Ig (CRIg), which is not expressed by neutrophils (Helmy et al., 2006).”