Complement - a key system for immune surveillance and homeostasis

By D. Ricklin, G. Hajishengallis, Kun Yang, John D Lambris. Nature Immunology, 2010

3,649 citations recorded by the source corpus.

Nearly a century after the significance of the human complement system was recognized, we have come to realize that its functions extend far beyond the elimination of microbes. Complement acts as a rapid and efficient immune surveillance system that has distinct effects on healthy and altered host cells and foreign intruders. By eliminating cellular debris and infectious microbes, orchestrating immune responses and sending 'danger' signals, complement contributes substantially to homeostasis, but it can also take action against healthy cells if not properly controlled. This review describes our updated view of the function, structure and dynamics of the complement network, highlights its interconnection with immunity at large and with other endogenous pathways, and illustrates its multiple roles in homeostasis and disease.

Subfields: Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/aa512601e19d0aeba1e9fe2f538f33c3138806b9

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Citations in the corpus

A Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and the Complement Pathway (2011, background): “The C3aR requirement for the P. gingivalis effect on the oral microbiota and bone loss may be related to its synergistic interactions with C5aR that include reciprocal augmentation of receptor expression (Ricklin et al., 2010).”
The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “In parallel, because some activated fragments of the complement are pro-inflammatory cytokines (C3a and C5a), systemic reactions [59] and adaptive immunity can occur via chemotaxis [56].”
The complement system: an unexpected role in synaptic pruning during development and disease. (2012, background): “In addition, the complement system clears modified self cells, such as apoptotic cells and cellular debris, to protect against autoimmunity (reviewed in Medzhitov & Janeway 2002, Carroll 2004, Zipfel et al. 2007, Ricklin et al. 2010).”
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis (2018, background): “ways (15), and results in proteolytic processing of various components of the complement system, including C3, C4, and C5.”
Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “Figure 1 demonstrates the different pathways that trigger the complement system and how physicochemical properties of nanomaterials can switch the activation process from one pathway to another [49-55].”
Complement System Part II: Role in Immunity (2015, background): “The complement system plays a major role in the tolerogenic perception of apoptosis, which is in partmediated by opsonization with C1q and iC3b and subsequent clearance of dying cells (4, 5) (Figure 2B).”
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera (2020, positive): “In the complement system, binding of mannose to lectin leads to cleavage of C2 and C4, which then form a C3 convertase to promote complement activation (Ricklin et al., 2010).”
Ischemia and reperfusion—from mechanism to translation (2011, background): “The complement system acts as an immune surveillance system to discriminate among healthy host tissue, cellular debris, apoptotic cells and foreign intruders, varying its response accordingl”
Complement System Part I – Molecular Mechanisms of Activation and Regulation (2015, background): “Complement is a central part of the innate immunity that serves as a first line of defense against foreign and altered host cells (1).”
Platelets in Inflammation and Atherogenesis (2015, background): “This cascade of soluble plasma proteins constitutes a phylogenetically very old part of the inherited immune system (117).”