DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

By A. Takaoka, Zhichao Wang, M. Choi, H. Yanai, Hideo Negishi, T. Ban, Yan Lu, M. Miyagishi, T. Kodama, K. Honda and 2 more. Nature, 2007

1,793 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/f9adfc6ec7a4f2509336128a0e5f79dd2356c976

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In Immunology

Citations in the corpus

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase (2013, neutral): “Indeed, in recent years, many cytoplasmic DNA sensors have been identified, including DAI (DNA-dependent activator of IFN-regulatory factor) (Takaoka et al., 2007), LRRFIP1 (leucine-rich repeat and flightless I interacting protein 1) (Yang et al.”
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells (2011, methodology): “Consistent with this model, it has been recently shown using quantitative proteomics that the CD8+ DC subpopulation selectively lacks the receptors and signaling molecules (such as DAI [Takaoka et al., 2007] and Sting [Ishikawa et al.”
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β (2008, background): “TLR3, TLR7 and TLR9 signal from endolysosomes, whereas the RNA helicases RIG-I and MDA-5 and the DNA sensor DAI signal from the cytosolic compartmen”
RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “Although DNA-dependent activator of IFN-regulatory factors (DAI) was identified as a possible DNA sensor (8), DAI knockout (KO) mice showed no abnormality in DNA-induced IFN production (9), suggesting that uncharacterized DNA sensor(s) could be functionally redundant.”
Pattern recognition receptors and inflammation. (2010, background): “A cytoplasmic DNA-binding protein, DNA-dependent activator of IRF (DAI, also known as Zbp1 or DLM1), interacts with TBK1 and activates type I IFN responses (Takaoka et al., 2007).”
Inflammation and its role in age-related macular degeneration (2016, background): “In contrast to other DNA sensors, such as DAI (DNA-dependent activator of IFN-regulatory factors) and one other PYHIN protein, IFI16 (interferon gamma-inducible protein 16), AIM2 does not mediate the type I IFN production [58, 59].”
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome (2009, background): “Recognition of cytoplasmic DNA is less well understood and is believed to be mediated by DAI (also called DLM-1 or ZBP1”
Recognition of microorganisms and activation of the immune response (2007, background): “26 ), whereas viral DNA is detected by the recently identified protein DA”
Pathogen Recognition by the Innate Immune System (2011, background): “In vitro studies, show that DAI is essential for type International Reviews of Immunology I interferon production via TBK1/IKKi [77]; however, genetic studies show that DAI is not essential for type I interferon production after the introduction of DNA, suggesting that cells possess an unidentified ”
The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis (2012, neutral): “Both DAI and TRIF recruit RIP1 and/or RIP3 through their RHIMs to activate NF-kB or to induce cell death (Kaiser and Offermann, 2005; Meylan et al., 2004; Takaoka et al., 2007).”
Immune sensing of DNA (2013, neutral): “DAI was shown to colocalize, and to interact in vitro with, dsDNA and reduction of HSV-1-induced IFN-b expression in the murine fibroblast cell line L929 was observed after DAI knockdown (Takaoka et al., 2007).”
Necroptosis: Mechanisms and Relevance to Disease (2016, neutral): “ZBP1 responds to exogenous DNA in the cytosol by promoting the synthesis of type I interferon (IFN) and downstream components of type I IFN responses (96, 97), as well as by activating NF-κ B signaling (93, 98).”
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (2009, background): “that the DNA signaling pathway is distinct from the RIG-I pathway (Ishii et al., 2006; Sun et al., 2006 ).”