RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

By Y. Chiu, J. MacMillan, Zhijian J. Chen. Cell, 2009

1,233 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a3bcdc77ff7b9505449e04300087efed64128a79

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Oncology

Citations in the corpus

Structural and functional insights into pattern recognition by the innate immune receptor RIG-I (2010, background): “In addition, it has been shown that, besides viral RNA, RNA helicase RIG-I is also activated by RNA polymerase III–mediated conversion of microbial DNA into 5′-ppp dsRN”
Searching for New Z-DNA/Z-RNA Binding Proteins Based on Structural Similarity to Experimentally Validated Zα Domain (2022, background): “Rpc34 (Q921X6) DNA-directed RNA polymerase III subunit RPC6 Mus musculus Eukarya 316 Nucleus/Nuclear and cytosolic DNA sensor involved in innate immune response, defence response to the virus [79]”
STING is a direct innate immune sensor of cyclic-di-GMP (2011, background): “By contrast, the induction of IFN by poly(dA-dT)dpoly(dT-dA) DNA (denoted poly(dAT:dTA)) was identical in cells that were transfected with wild-type Sting and those transfected with gt , demonstrating that the RNA polymerase III DNA-sensing pathwa”
Pattern Recognition Receptors and the Innate Immune Response to Viral Infection (2011, background): “This indirect DNA-sensing system was also reported to be involved in induction of type I IFN following HSV-1 or Legionella infection [52,55,57].”
Cytosolic Sensing of Viruses (2013, background): “Initial conflicting data reporting a role for MAVS as an adaptor in the cytosolic DNA response led to the discovery of RIG-I as an ‘‘indirect’’ sensor of some types of DNA (Ablasser et al., 2009; Chiu et al., 2009) (Figure 4).”
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response (2009, background): “Recent studies have shown that the poly (dA-dT), B-form of dsDNA used in this study, induces RNA polymerase III-dependent innate immune responses both in human cells and in immortalized mouse cells (28, 29).”
STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway (2012, background): “Studies have shown that DNA-dependent RNA polymerase III (Pol III) converts AT-rich DNA, such as poly(dA:dT), into an RNA species that triggers the RIG-I pathway (10, 11).”
cGAS is essential for cellular senescence (2017, background): “In the course of studying cytosolic DNA sensing, we and others previously found that some transformed cells such as HEK293T cells and some immortalized MEF cells lost the ability to induce type I interferons in response to transfected DNA (22, 32, 33).”
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells (2011, background): “RIG-I senses cytosolic DNA (B-form DNA) via RNA polymerase III to trigger responses by transcription factor IRF3–dependent type I interfero”