DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

By Steen K. T. Ooi, C. Qiu, E. Bernstein, Keqin Li, D. Jia, Zhe Yang, H. Erdjument‐Bromage, Paul Tempst, Shau-Ping Lin, C. D. Allis and 2 more. Nature, 2007

1,595 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f929be5f26e895c17d897ed795f2a575b2b9f72c

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Citations in the corpus

A double take on bivalent promoters. (2013, background): “H3K4me3 interferes with the recruitment of the de novo DNA methyltransferases DNMT3A and DNMT3B (Ooi et al. 2007; Zhang et al. 2010), enforcing the mutual exclusion of these marks.”
CpG islands – ‘A rough guide’ (2009, background): “However, DNMT3L cannot bind to chromatin in which the Histone H3 tails are tri-methylated at the lysine 4 position [54].”
DNA methylation: a historical perspective. (2022, neutral): “This provided experimental evidence that DNMT activity can be directly blocked by a specific histone modification [195] (Figure 5C).”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and may therefore induce de novo DNA methylation by recruitment and activation of DNMT3A2.(54) In mammals, there are at least 10 known or predicted H3K4 methyltransferases, which are generally categorized into the MLL (mixed lineag”
Modification of enhancer chromatin: what, how and why? (2013, background): “One of the main substrates acetylated by p300/CBP in vivo is H3K27 (Jin et al., 2011; Pasini et al., 2010; Tie et al., 2009) (Figure 4).”
Rethinking how DNA Methylation Patterns are Maintained (2009, neutral): “Perhaps one of the most definitive biochemical demonstrations of the potential mechanisms for de novo methylation during germ cell development came from the seminal work of Ooi et al”
Linking DNA methylation and histone modification: patterns and paradigms (2009, background): “Recent studies strongly suggest that the establishment of the basic DNA methylation profile during early development might be mediated through histone modificatio”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “For example, an elegant tetrameric complex has been defined that can neatly surround a nucleosome and presumably initiate methylation in this contex”
Establishing, maintaining and modifying DNA methylation patterns in plants and animals (2010, background): “Biochemical purification of DNMT3L led to the discovery that DNMT3L interacts with unmethylated H3K4 tails through its cysteine-rich ATRX–DNMT3–DNMT3L (ADD) domai”
Charting histone modifications and the functional organization of mammalian genomes (2011, background): “For instance, methylation of H3K4 was shown to preclude a physical interaction between the histone tail and DNA methyltransferase 3-like protein (DNMT3L”
Dynamic CpG island methylation landscape in oocytes and preimplantation embryos (2011, background): “In addition, interaction of DNMT3A and DNMT3L with chromatin is inhibited by H3K4 methylatio”