Establishing, maintaining and modifying DNA methylation patterns in plants and animals

By Julie A. Law, Steven E. Jacobsen. Nature reviews genetics, 2010

3,608 citations recorded by the source corpus.

Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and transposon silencing, imprinting and X chromosome inactivation. Recent findings in plants and animals have greatly increased our understanding of the pathways used to accurately target, maintain and modify patterns of DNA methylation and have revealed unanticipated mechanistic similarities between these organisms. Key roles have emerged for small RNAs, proteins with domains that bind methylated DNA and DNA glycosylases in these processes. Drawing on insights from both plants and animals should deepen our understanding of the regulation and biological significance of DNA methylation.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/6e8a496897ee343e0aa0ee46e337d7d2d04a1870

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Plant Science

Citations in the corpus

Abscisic Acid and Abiotic Stress Tolerance in Crop Plants (2016, background): “In plants, cytosines in the contexts of CG, CHG, and CHH (H = A, C, or T) can be methylated (Law and Jacobsen, 2010).”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “An additional class of DCL3-dependent small RNAs, heterochromatic small interfering RNA, are generated in the nucleus and loaded into AGO4 in the cytoplasm prior to import into the nucleus (Ye et al., 2012), where they act in RNA-directed DNA methylation (reviewed in Law and Jacobsen, 2010).”
DNA methylation on N6-adenine in C. elegans (2015, positive): “In Arabidopsis, for example, the RNAi pathway feeds into 5mC regulation and heterochromatin formation and propagation (Law and Jacobsen, 2010; Teixeira et al., 2009; Wassenegger et al., 1994).”
Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications (2011, positive): “In plants, methylation is quite common in both the symmetric CpG or CHG, and asymmetric CHH context (whereby H can be either A, T or C) (Feng et al., 2010; Law and Jacobsen, 2010).”
Spontaneous epigenetic variation in the Arabidopsis thaliana methylome (2011, background): “Transposable elements and short interfering RNAs have been causally linked to DNA methylatio”
Evolution and Functional Diversification of MIRNA Genes (2011, background): “…functional state that mediates the recruitment, either directly or indirectly, of RDR6 (Chen et al., 2010; Cuperus et al., 2010a). miRNA-Directed DNAMethylation A subset of miRNA variants preferentially associate with AGO proteins involved in RNA-directed DNA methylation (Law and Jacobsen, 2010).”
DNA Demethylation Dynamics (2011, background): “DNMT3A and 3B are responsible for de novo DNA methylation, whereas DNMT1 maintains DNA methylation patterns through successive rounds of cell division.”
Epigenomic diversity in a global collection of Arabidopsis thaliana accessions (2016, neutral): “In plants, DNAmethylation occurs in the symmetric contexts CG andCHG (H =C, A, or T), and the asymmetric context CHH (Law and Jacobsen, 2010).”
Charting histone modifications and the functional organization of mammalian genomes (2011, background): “At the root are the DNA sequence and its direct chemical modification by cytosine methylatio”