Expression of Hepatitis C Virus Proteins Induces Distinct Membrane Alterations Including a Candidate Viral Replication Complex

By D. Egger, B. Wölk, R. Gosert, L. Bianchi, H. Blum, D. Moradpour, K. Bienz. Journal of Virology, 2002

956 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/f8f72e96201a2075154e78aaafe578aec4132b09

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Charles M. Rice
2. Brett D. Lindenbach Heinz-J

In Hepatology

1. Charles M. Rice
2. Brett D. Lindenbach Heinz-J
3. B. Lindenbach
4. D. Moradpour
5. François Penin
6. Ralf Bartenschlager

In Radiology, Nuclear Medicine and Imaging

1. Charles M. Rice

Citations in the corpus

• Replication of hepatitis C virus (2007, background): “One of its functions is to induce the formation of the membranous web, the specific membrane alteration that serves as a scaffold for the HCV replication comple”
• The lipid droplet is an important organelle for hepatitis C virus production (2007, neutral): “The HCV replication complex is compartmentalized by lipid bilayer membrane”
• Unravelling hepatitis C virus replication from genome to function (2005, background): “In replicon-bearing cells, HCV NS proteins, RNA and RdRP activity associate with ultrastructural vesicular structures termed the ‘membranous web’, which also resembles the membrane alterations seen in hepatocytes from HCV-infected live”
• Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons (2003, background): “This result is in perfect agreement with our previous observations using tetracycline-regulated cell lines (9).”
• Modification of intracellular membrane structures for virus replication (2008, background): “The membrane rearrangements that are involved in RNA replication of HCV, a member of the Flaviviridae family that belongs to the Hepacivirus genus, constitute the membranous web 16, 17 .”
• Flaviviridae :T he Viruses and Their Replication (2007, background): “Regardless of their origin, formation of the membranous web is induced by NS4B expression (167), and may activate ER stress pathways (697).”
• Immunology of hepatitis B virus and hepatitis C virus infection (2005, neutral): “Following synthesis and maturation, non-structural proteins and viral RNA form membrane-associated replication complexes, which appear as a perinuclear membranous we”