Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

By R. Gosert, D. Egger, V. Lohmann, Ralf Bartenschlager, H. Blum, K. Bienz, D. Moradpour. Journal of Virology, 2003

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Flaviviridae :T he Viruses and Their Replication (2007, background): “Expression of NS4B is sufficient to induce the formation of the “membranous web” structures characteristic of HCV RNA replication complexes (167,233).”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “It localizes to active replication complexes (Gosert et al., 2003; Moradpour et al., 2004), interacts with NS5B and inhibits its RNA polymerase activity (Shirota et al.”
Unravelling hepatitis C virus replication from genome to function (2005, background): “In replicon-bearing cells, HCV NS proteins, RNA and RdRP activity associate with ultrastructural vesicular structures termed the ‘membranous web’, which also resembles the membrane alterations seen in hepatocytes from HCV-infected live”
Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites (2009, background): “In cells either containing a persistently replicating subgenome or infected with HCV, intensive structural rearrangements, designated the membranous web, were found (Gosert et al., 2003; Miller and Krijnse-Locker, 2008).”
Replication of hepatitis C virus (2007, background): “A specific membrane alteration, named the membranous web, was identified as the site of RNA replication in Huh-7 cells containing subgenomic HCV replicon”