Modification of intracellular membrane structures for virus replication

By S. Miller, J. Krijnse-Locker. Nature Reviews Microbiology, 2008

772 citations recorded by the source corpus.

Viruses are intracellular parasites that use the host cell they infect to produce new infectious progeny. Distinct steps of the virus life cycle occur in association with the cytoskeleton or cytoplasmic membranes, which are often modified during infection. Plus-stranded RNA viruses induce membrane proliferations that support the replication of their genomes. Similarly, cytoplasmic replication of some DNA viruses occurs in association with modified cellular membranes. We describe how viruses modify intracellular membranes, highlight similarities between the structures that are induced by viruses of different families and discuss how these structures could be formed.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/10166f184f171fb8b01aedc043b11cd16c3a627a

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Citations in the corpus

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites (2009, background): “Colocalization studies performed, especially with the poliovirus, have suggested a role for autophagy in the biogenesis of viral RCs as well as virus assembly and release (reviewed in Miller and Krijnse-Locker, 2008).”
Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication (2010, background): “Cells infected with plus-strand RNA viruses undergo a dramatic remodeling of their intracellular membranes, and RNA replication frequently takes place on the cytosolic leaflet of these remodeled membranes (Dales et al., 1965; Miller and Krijnse-Locker, 2008; Salonen et al., 2005).”
Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles (2016, background): “In addition, the ROs are believed to protect viral RNAs against degradation by cellular RNases and/or detection by RNA sensors that trigger antiviral responses (reviewed in [14] [15] [16] ).”
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum (2008, background): “The fact that the replication complexes of positive-strand RNA (þRNA) viruses of eukaryotes are invariably associated with (modified) intracellular membranes appears to be a striking example of such a strategy [1] [2] [3] [4] [5] [6] [7] [8] .”
Dengue virus induced autophagy regulates lipid metabolism (2010, background): “After virion endocytosis and uncoating, DENV proteins are translated and establish membranous replication complexes in the cytosol that facilitate efficient viral RNA replication (Miller and Krijnse-Locker, 2008).”