Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.
By M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, K. Takaya, T. Hayashi, G. Inoue, K. Hosoda, M. Kojima and 2 more. Diabetes, 2001
835 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Reproductive Medicine
View Paper: https://www.semanticscholar.org/paper/f87ddc7d03c8d26c039d408b5f6bbb03e7c6e470
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In Endocrine and Autonomic Systems
In Nutrition and Dietetics
Citations in the corpus
- Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. (2002, methodology): “Human Tyr-ghrelin [13–28] was radioiodinated by the lactoperoxidase method for use in the assay.”
- Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “According to current knowledge, it seems that two major hypothalamic pathways are the predominant mediators of ghrelin’s influence on energy balance (39, 159, 353).”
- Deletion of Ghrelin Impairs neither Growth nor Appetite (2003, background): “Furthermore, leptin-induced inhibition of food intake is reversed by intracerebroventricular coinjection of ghrelin ( 26 ).”
- Anatomy and regulation of the central melanocortin system (2005, background): “Such doses also stimulate food intake and obesity, in part by stimulating NPY and AgRP expressio”
- The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. (2003, background): “Shintani et al., 2001) and data showing colocalization Model of proposed sites of ghrelin activity in the hypothalamus.”
- Studies on the physiological functions of the melanocortin system. (2006, background): “Stimulation of food intake by ghrelin administration is blocked by administration of NPY/Y1 and Y5 antagonists (101), and reduced in the NPY / mouse.”
- A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. (2001, background): “A role for NPY and AGRP as mediators of ghrelin’s feeding effects is suggested by studies in which antagonism of either NPY or AGRP signaling in the brain was shown to attenuate the orexigenic potency of injected ghrelin (4,6,12).”
- Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. (2001, background): “2 4754 J Clin Endocrinol Metab, October 2001, 86(10):4753–4758 Ariyasu et al.”
- Ghrelin: structure and function. (2005, background): “The ARC is also a target of leptin, an appetite-suppressing hormone produced in adipose tissues, and NPY and AgRP, which are both appetite-stimulating peptides (76, 163).”
- Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. (2004, background): “Our results are consistent with pharmacological studies indicating that antibodies directed against NPY or NPY receptor Y1 antagonists could attenuate ghrelin-induced food intake (3, 12).”